Silybin
CommonNameSilybin
CASnumber:22888-70-6Activeingredients:Silybinisthemixtureoftwodiastereomers,silybinAandsilybinB,inapproximatelyequimolarratio.BothinvitroandanimalresearchsuggestthatSilybinhashepatoprotective(antihepatotoxic)propertiesthatprotectlivercellsagainsttoxins.ProductCharacteristics:BotanicalNameSilybummarianumPlantPartSeedsofS.marianumPurity≥98%(mixtureoftwodiastereomers,silybinAandsilybinB)Stability≥2yearsat-20CSuppliedAscrystallineYellowpowder.SolventEthanol,DMSO,andDimethylformamideCountryofOriginChinaProductInformationSilybinissparinglysolubleinaqueousbuffers.Formaximumsolubilityinaqueousbuffers,silybinshouldfirstbedissolvedinDMFandthendilutedwiththeaqueousbufferofchoice.Silybinhasasolubilityofapproximately0.5mg/mlina1:9solutionofDMF:PBS(pH7.2)usingthismethod.Wedonotrecommendstoringtheaqueoussolutionformorethanoneday.Rangeofapplication:Silybinisthemajorflavonolignanfromtheextractsofmilkthistleseed,S.marianum.Thewholeextract,knownassilymarin,hasbeenfoundtoprotecttheliverfrombothacuteandchronictoxicityandinjury.SilybinblockstheproductionofsuperoxideinPMA-activatedratKupffercellswithanECvalueofaround100µM.SilybinalsoblocksthesynthesisofleukotrieneBbythesesamecellswithanIC50valueofabout15µM.Thus,partoftheprotectiveeffectsofsilybincouldbedueto5-lipoxygenaseinhibition.Storage≥2yearsat-20°CPacking25kgbarrel//CanorDependsonrequirements.ProductcustomizationAccordingtocustomerqualitystandardsforcustomization**OurAdvantages:Wespecializeinplantextract,aminoacid,API&intermediates,foodadditive,nutraceuticalsupplementetc.Ourbusinesseshavealreadyextendedtomorethan50countriesthatseparatelylocatedinEurope,America,East&SoutheastAsia,AfricaandOceania.Wehave:extensiveexperience,professionalR&Dandsalesteam,strictqualitycontrol,competitiveprice.
ProductcustomizationAccordingtocustomerqualitystandardsforcustomization**
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