Salvianolic Acid B
Clinical Application
This product has the effect of promoting blood circulation and removing blood stasis. It is effective in relieving meridian stroke caused by blood stasis. It is caused by numbness of limbs, weakness, weakness, pain, or movement, and eyelid dislocation.
Pharmacological Efficacy
Salvianolic acid B is a combination of three molecules of Danshensu and one molecule of caffeic acid. It is one of the most studied salvianolic acids and has important pharmacological effects on organs such as heart, brain, liver and kidney.
Anti-oxidation
Salvianolic acid B has a strong anti-oxidation effect. In vitro and in vivo experiments prove that salvianolic acid B can scavenge oxygen free radicals and inhibit lipid peroxidation. Its intensity is higher than Vitamin C , Vitamin E and Mannitol. One of the most known natural products with the strongest antioxidant effect . Pharmacological studies have shown that salvianolic acid for injection has obvious antioxidant effects, inhibits platelet aggregation, inhibits thrombosis, and prolongs animals under hypoxic conditions. Survival time.
Protect the heart
1 Protective effect on myocardial ischemia-reperfusion injury
2 Delayed protection of cardiac microvascular endothelial cells
3 Prevention and treatment of atherosclerosis
4 Effects on apoptosis
5 Pre-adapted heart cell protection.
Protect the brain
1 Protective effect on cerebral ischemic injury
2 Effects on learning and memory function
Fibrosis
Salvianolic acid B can suppress the expression of TGF- β I HSC intracellular signal transduction and protein receptors, thereby antagonizing the pro-TGF- β 1 HSC activation,proliferation and inhibit activation FSC, FSC suppressing the generation of extracellular matrix Reduce the deposition of collagen fibers in the liver. Other studies have shown that salvianolic acid B magnesium salt has anti-lipid peroxidation and anti-liver damage, and has the function of reducing liver tissue fibrosis. It is clinically used to treat liver fibrosis of chronic hepatitis B with satisfactory results .
Antitumor
Studies have shown that salvianolic acid B not only protects nerve cells through antioxidant action, but also improves the toxic effects of J3- amyloid on neurons by reducing the release of NO . It can enhance the aging of red blood cells and increase the secretion of IL-238 by T lymphocytes , which has anti-aging and anti-tumor effects.
In vivo and in vitro experiments show that salvianolic acid B magnesium salt has a good inhibitory effect on the growth of a variety of tumor cell lines. According to research experiments, salvianolic acid B may play an anti-tumor role by inducing apoptosis of prostate tumor cells.
Other Effects
Salvianolic acid B can promote the transformation of bone marrow stromal cells into cardiomyocyte-like cells in vitro, and can be used as a good cell source for cell surgery, and explore a new way for cell-based myocardial angioplasty.
In addition, salvianolic acid B magnesium salt can also be used for preventing or treating nephritis, renal failure, vasculitis, venous thrombosis, senile dementia disease, anti-aging, affecting sodium potassium ATPase , H+ , K+-ATPase activity, etc.
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