Solid Phase Peptide Synthesis
Peptide Synthesis Resins
Since Solid Phase Peptide Synthesis was first proposed by Robert Bruce Merrifield, the method of synthetic peptides became more popular than liquid phase peptide synthesis because of high efficiency. This method could assemble a peptide chain rapidly through successive reactions of amino acid derivatives on an insoluble support.
The original peptide antibiotics are also biosynthesized and extracted from the culture of polymyxa or aeruginosa. Another synthetic method of peptides is chemical synthesis, which is divided into liquid phase chemical synthesis and solid phase chemical synthesis. The liquid phase method is mainly used for the synthesis of short peptides. The solid phase synthesis method can be used to prepare long-chain peptides, cyclic peptides, and complex. Peptide. The solid phase method is divided into a Boc method and an Fmoc method. It requires the solid phase synthesis of the carrier to achieve the growth of the peptide chain by means of stepwise amino acid condensation. The advantages of solid phase synthesis are ease of purification, shortening of the synthesis cycle, and ease of automation.
Solid phase peptide synthesis(SPPS) support consists of small, polymeric resin beads functionalized with reactive group such as amine or hydroxyl groups, which link to systhesis peptide chain step by step.
Solid phase peptide synthesis(SPPS) resins is insoluble in all common solvents but swells well in most organic solvents. Better swelling degree is benefit for the reaction yields, but for short peptide easy to synthesis, lower swelling degree will be suitable and it will be good at saving solvent.
Solid phase peptide synthesisResins are rich in variety, complete in specifications and stable in performance.
Typical Applications
Solid phase synthesis of Bivalirudin
Solid phase synthesis of Eptifibatide
Solid phase synthesis of Exenatide
Solid phase synthesis of Liraglutide
Solid phase synthesis of thymopentin
Solid phase synthesis of Thymalfasin
Solid phase synthesis of Buserelin
Solid phase synthesis of Goserelin
Solid phase synthesis of Octreotide
Solid phase synthesis of Calcitonin
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We also have good experiences in research and develop the amine acid pre-loading peptide resins, and we have extended resin backbone to hydrophilic matrix, such as DEG series, TEG series, PEG series. Welcome to ask for Sunresin!
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