25-OH Vitamin D
Vitamin D is converted to 25-hydroxyvitamin D (25-OH-VD) by hydroxylation in the liver and the active 1, 25-dihydroxy vitamin D in the kidneys.
25 hydroxyvitamin D is the main form of vitamin D in the body.
The level of serum vit 25 oh dcan reflect the level of vitamin D storage and correlate with the clinical symptoms of vitamin D deficiency.
Similar to other steroid hormones, 1, 25-dihydroxy vitamin D3 regulates tissue cell differentiation and related gene expression, mainly regulating blood calcium level and affecting cell differentiation.
25 0h vitamin dhas a high content in blood and a long half-life.
It is stable and is not directly affected by diet and lifestyle. Therefore, clinical measurement of 25-OH-VD can reflect the proper level of vitamin D in vivo.
25OHVitamin D Intro
25-hydroxyvitamin D is the main form of vitamin D in the body. Vitamin D is a steroid derivative, is a fat-soluble vitamin, and is a cyclopentane poly hydro phenanthrene compound. Vitamin D is mainly synthesized by human skin after being irradiated by ultraviolet rays, and a small part is ingested from food or supplements. Vitamin D affects calcium and phosphorus metabolism and has a wide range of physiological effects. It is an indispensable substance for maintaining human health, cell growth, and development and is closely related to various diseases. There are two forms of vitamin D in the human body, vitamin D3 (cholecalciferol) and vitamin D2 (ergocalciferol), which are converted to 25-hydroxyvitamin D (25-OH-VD) by hydroxylation in the liver, which is then converted to active 1,25-dihydroxy vitamin D in the kidneys. The serum 25-OH-VD can reflect human vitamin D storage level, which is related to the clinical symptoms of vitamin D deficiency.
Vitamin D Antibody
Vitamin D is an important hormone that regulates calcium and phosphorus metabolism in the body. The skin mainly synthesizes it under sunlight conditions, and a small amount can obtain through diet. The active form of vitamin D is especially 1,25 dihydroxy vitamin D3 (1,25(OH) 2 D 3 ), which exerts physiological effects by binding to the vitamin D receptor (VDR). 25-hydroxyvitamin D (25(OH)D) is the body's primary storage form of vitamin D. 1,25(OH)D3 induces the differentiation of monocytes into macrophages and reduces the release of inflammatory cells and chemokines.
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