(R)-3-(Boc-Amino)piperidine
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CAS Number: .
Molecular Formula: C10H20N2O2.
Molecular Weight: 200.28.
Appearance: White crystalline powder.
Boiling Point: 304.8°C at 760 mmHg.
| Attribute | Details |
|---|---|
| Chemical Name | (R)-3-(Boc-Amino)piperidine |
| CAS Number | |
| Synonyms | (R)-3-Boc-Aminopiperidine; (R)-3-tert-Butoxycarbonylaminopiperidine; tert-butyl (3R)-piperidin-3-ylcarbamate; (R)-3-N-BOC-AMINO-PIPERIDINE |
| Formula | C10H20N2O2 |
| Molecular Weight | 200.28 g/mol |
| Appearance | White to off-white solid |
| Melting Point | 121.0 to 125.0 °C |
| Boiling Point | 304.8°C at 760 mmHg |
| Density | 1.02 g/cm³ |
| Solubility | Poorly soluble in water, but soluble in alcoholic organic solvents such as methanol and ethanol |
| Optical Activity | [α]22/D +3.2°, c = 0.5 in DMF |
| pKa | 12.37±0.20 (Predicted) |
| Usage | Used as an intermediate in organic synthesis and pharmaceutical chemistry, particularly for the synthesis and modification of drug molecules and biologically active molecules. It is a key intermediate in the synthesis of drugs like Linagliptin and Alogliptin, which are inhibitors of dipeptidyl peptidase-4 (DPP-4) used for lowering blood glucose levels. |
| Safety Information | Xi, N; R37/38-41-50; Keep away from heat, sparks, and open flames. Avoid contact with skin and eyes. In case of contact, rinse immediately with plenty of water and seek medical advice. |
| Supplier | Various companies such as E’meishan Hongsen Biomedicine Co., Ltd., Chongqing Inskay Pharmaceutical Co., Ltd., Shandong Sihuan Pharmaceutical Co., Ltd., and Anqing Qichuang Pharmaceutical Co., Ltd. |
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