Dopamine hydrochloride
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CAS Number: 62-31-7
Molecular Formula: C8H12ClNO2
Molecular Weight: 189.64
Appearance: White or grayish white crystalline powder
Melting Point: 240-250°C (decomposes)
Solubility: Soluble in water, slightly soluble in alcohol.
| Category | Details |
|---|---|
| Chemical Name | Dopamine hydrochloride |
| CAS Number | 62-31-7 |
| Synonyms | Dopamine HCl; 3-Hydroxytyramine hydrochloride; 4-(2-Aminoethyl)-1.2-benzenediol hydrochloride; Dihydroxyphenethylamine hydrochloride |
| Formula | C8H11NO2 · HCl |
| Molecular Weight | 189.64 g/mol |
| Appearance | White or almost white, crystalline powder |
| Melting Point | 248-250°C (lit.) |
| Boiling Point | 337.7°C at 760 mmHg |
| Solubility | Freely soluble in water, soluble in methanol and ethanol, slightly soluble in chloroform and ether |
| Stability | Light sensitive. Store in a cool, dry place, protected from light. |
| Pharmaceutical Form | Injection (as hydrochloride salt) |
| Therapeutic Uses | Used in the treatment of various types of shock, including septic, cardiogenic, hemorrhagic, and central shock. It is also used in patients with renal insufficiency, decreased cardiac output, and increased peripheral vascular resistance who have received adequate fluid volume replacement. |
| Mechanism of Action | Acts directly on the dopaminergic receptors and also stimulates α- and β2-adrenergic receptors. It increases systolic blood pressure by reducing renal and mesenteric vascular resistance, with minimal change in diastolic blood pressure. |
| Side Effects | May include nausea, vomiting, headaches, and central nervous system stimulation. Large doses may cause tachycardia and arrhythmias. |
| Precautions | Should be used cautiously in patients with hypersensitivity to the drug, pheochromocytoma, hyperthyroidism, or uncorrected tachycardia or ventricular fibrillation. |
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