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Dopamine hydrochloride

CAS Number: 62-31-7

Molecular Formula: C8H12ClNO2

Molecular Weight: 189.64

Appearance: White or grayish white crystalline powder

Melting Point: 240-250°C (decomposes)

Solubility: Soluble in water, slightly soluble in alcohol.

CategoryDetails
Chemical Name Dopamine hydrochloride
CAS Number 62-31-7
Synonyms Dopamine HCl; 3-Hydroxytyramine hydrochloride; 4-(2-Aminoethyl)-1.2-benzenediol hydrochloride; Dihydroxyphenethylamine hydrochloride
Formula C8H11NO2 · HCl
Molecular Weight 189.64 g/mol
Appearance White or almost white, crystalline powder
Melting Point 248-250°C (lit.)
Boiling Point 337.7°C at 760 mmHg
Solubility Freely soluble in water, soluble in methanol and ethanol, slightly soluble in chloroform and ether
Stability Light sensitive. Store in a cool, dry place, protected from light.
Pharmaceutical Form Injection (as hydrochloride salt)
Therapeutic Uses Used in the treatment of various types of shock, including septic, cardiogenic, hemorrhagic, and central shock. It is also used in patients with renal insufficiency, decreased cardiac output, and increased peripheral vascular resistance who have received adequate fluid volume replacement.
Mechanism of Action Acts directly on the dopaminergic receptors and also stimulates α- and β2-adrenergic receptors. It increases systolic blood pressure by reducing renal and mesenteric vascular resistance, with minimal change in diastolic blood pressure.
Side Effects May include nausea, vomiting, headaches, and central nervous system stimulation. Large doses may cause tachycardia and arrhythmias.
Precautions Should be used cautiously in patients with hypersensitivity to the drug, pheochromocytoma, hyperthyroidism, or uncorrected tachycardia or ventricular fibrillation.

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