Dopamine hydrochloride

CAS Number: 62-31-7

Molecular Formula: C8H12ClNO2

Molecular Weight: 189.64

Appearance: White or grayish white crystalline powder

Melting Point: 240-250°C (decomposes)

Solubility: Soluble in water, slightly soluble in alcohol.

Category	Details
Chemical Name	Dopamine hydrochloride
CAS Number	62-31-7
Synonyms	Dopamine HCl; 3-Hydroxytyramine hydrochloride; 4-(2-Aminoethyl)-1.2-benzenediol hydrochloride; Dihydroxyphenethylamine hydrochloride
Formula	C8H11NO2 · HCl
Molecular Weight	189.64 g/mol
Appearance	White or almost white, crystalline powder
Melting Point	248-250°C (lit.)
Boiling Point	337.7°C at 760 mmHg
Solubility	Freely soluble in water, soluble in methanol and ethanol, slightly soluble in chloroform and ether
Stability	Light sensitive. Store in a cool, dry place, protected from light.
Pharmaceutical Form	Injection (as hydrochloride salt)
Therapeutic Uses	Used in the treatment of various types of shock, including septic, cardiogenic, hemorrhagic, and central shock. It is also used in patients with renal insufficiency, decreased cardiac output, and increased peripheral vascular resistance who have received adequate fluid volume replacement.
Mechanism of Action	Acts directly on the dopaminergic receptors and also stimulates α- and β2-adrenergic receptors. It increases systolic blood pressure by reducing renal and mesenteric vascular resistance, with minimal change in diastolic blood pressure.
Side Effects	May include nausea, vomiting, headaches, and central nervous system stimulation. Large doses may cause tachycardia and arrhythmias.
Precautions	Should be used cautiously in patients with hypersensitivity to the drug, pheochromocytoma, hyperthyroidism, or uncorrected tachycardia or ventricular fibrillation.

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