.

Anastrozole

Product Name:Anastrozole

Synonyms:Arimidex;1-[3,5-Di-(1-Methyl-1-Cyano)-Ethyl]-Benzyl-1,2,4-Triazole;

Anastrozole;tetramethyl-5-(1h-1,2,4-triazol-1ylmethyl) 1,3-benzenediacetionitrile;ZD-1033

CAS:

MF:C17H19N5

MW:293.37

Chemical properties:It can be crystallized from ethyl acetate-cyclohexane, the melting point is 81~82℃.

MP: 81-82°C

Storage Temp. :Store at RT

Usage:An aromatase inhibitor. Used as an antineoplastic.

Biological Activity:Potent and highly selective aromatase (CYP19) inhibitor (IC 50 = 15nM) that has no discernible effect on adrenocorticoid hormone synthesis. Reduces plasma estrogen levels and exhibits antitumor activity in vivo . Orally active.

Uses(1) It is the third-generation’s aromatase inhibitors, used for the treatment of advanced breast cancer of postmenopausal patients.

(2) Its used to cure the breast cancer.

(3) Anastrozole is the third-generation’s aromatase inhibitors, used for the treatment of advanced breast cancer of postmenopausal patients. It is an inhibitor for the triazole aromatase with a strong selectivity. It can inhibits aromatase which is prerequisite for the synthesis of pigment cells P-450 thereby blocking the biosynthesis of estrogens, and the estrogen is the essential part of the growth of breast cancer cells. Its used to cure the breast cancer, particularly suitable for postmenopausal women with advanced breast cancer who recrudescent after hormone adjuvant therapy.



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