Protective Agents (For Liposomes)
Excipients used in solid dosage forms, excipients used in formulation of tablets and excipients of liquid dosage form are very important to reduce or eliminate the damage to liposomes caused by the lyophilization process. Dehydration of liposomes can cause the transition from liquid crystal state to gel state of phospholipids, and rehydration of dried liposomes can also be accompanied by transition from gel state to liquid crystal state, both of which can cause leakage of liposome contents, particle size increasing and the transition from single-chamber to multi-chambers. Therefore, it is very important to select a suitable lyoprotectant to reduce or eliminate the damage to liposomes caused by the lyophilization process. AVT is a reliable supplier of excipients used in semi solid dosage forms and excipients for liquid dosage form.
TYPES OF PROTECTIVE AGENTS (FOR LIPOSOMES)
D(+)-Trehalose Dihydrate (For Injection) CAS NO 6138 23 4
(AVT brand trehalose dihydrate (for injection) is commonly used as lyoprotectants, besides it is also stabilizer and cryoprotectant for lipid nanoparticles and mRNA.
Sucrose (For Injection) CAS No.: 57-50-1
It is injectable grade sucrose of high purity and low endotoxin, which is often used in the pharmactutical industry as a lyoprotectant in nano-formulations and protein biologics.
D(+)-Trehalose Dihydrate (For Injection) (Sterile) CAS No.: 6138-23-4
It is sterile trehalose dihydrate with the characteristics of high glass transition temperature, low hygroscopicity and water retention. It is also heat resistant, acid resistant and extremely stable.
How do Protective Agents (ForLait Liposomes) Work?
The selection of freeze-drying protection agent is an important factor affecting the quality of freeze-drying. The freeze-drying process will lead to the aggregation and fusion of liposomes, accompanied by the leakage of liposome contents, while sucrose can reduce membrane fusion and protect the liposome particles from breaking and leaking drugs during the freeze-drying process. In addition, it can also act as excipients of semi solid dosage forms. If you want more detailed information such as excipients in pharmaceutical formulationsof liquid dosage forms ppt/pdf you can contact AVT.
在线联系供应商
Other supplier products
EGG YOLK LECITHIN CAS NO.: 93685-90-6 | Emulsification efficacy of lecithin from egg yolk cas no.:93685 90 6 is a critical factor to the quality of lipid emulsions. Better emulsification ... | |
Egg Yolk Lecithin Cas No.: 93685 90 6 | EGG YOLK LECITHIN CAS NO.: 93685 90 6 Emulsification efficacy of lecithin from egg yolk cas no.:93685 90 6 is a critical factor to the quality of ... | |
D(+)-TREHALOSE DIHYDRATE (FOR INJECTION) CAS NO 6138 23 4 | Trehalose CAS NO 6138 23 4 is highly cost-effective, injection grade, product quality in line with ChP, USP, JP, EP standards, Registered in US FDA... | |
SUCROSE OCTASULFATE POTASSIUM SALT CAS NO.: 73264 44 5 | • SUCROSE OCTASULFATE POTASSIUM SALT CAS NO.: 73264 44 5 has high purity, low endotoxin and in line with national pharmacopeia standard USP, t... | |
SUCROSE (FOR INJECTION) CAS NO.: 57-50-1 | SUCROSE (FOR INJECTION) CAS NO.: 57-50-1 It not only acts as a cryopreservative in the lyophilization process, but also acts as a dehydration prote... |
Same products
HPMC 粉末 | 卖方: 谊达纤维素 | 羟丙基甲基纤维素(HPMC)是采用精制棉经粉碎后,与氢氧化钠(液碱)溶液进行碱化反应,再加入二氯甲烷和环氧丙烷进行醚化反应,再经过介质混合、压制、干燥、筛分等一系列环节而制得,为无臭、无毒的白色... | |
UHMWPE Plant | 卖方: Hubei Sanli Fengxiang Technology Co., Ltd | Ultra high molecular weight polyethylene (hereinafter called as UHMWPE) is a linear structural po... | |
Formic acid production technology | 卖方: Hubei Sanli Fengxiang Technology Co., Ltd | There are totally four production processes forformic acid production, incl. Sodium Formate Proce... | |
PPC Plant | 卖方: Hubei Sanli Fengxiang Technology Co., Ltd | PPC (polypropylene carbonate)is acompletely biodegradable environment-friendly plastic synthesize... | |
Buy Caluanie Muelear Ship in Europe | 卖方: CALUANIE MUELEAR OXIDIZE | Caluanie (Oxidative Partition Thermostat, Heavy Water) Appearance: Transparent liquid. Smell: Ord... |