Contrast Media Manufacturing Company

For the purpose of medical imaging, a certain substance is introduced into the human body to change the image contrast of local tissues of the body. This introduced substance is Contrast Media, also known as Contrast Agents. Asone ofthe first contrast media manufacturing companiesin China, Beilu Pharma, as one of the most professional contrast media suppliers, contrast media companies, contrast media manufacturers, launched the domestic MRI Contrast MediumGadopentetate Dimeglumine Injection in 1992, which broke the foreign products monopoly and filled the domestic gap. As a well-known contrast media productscompany, we could provide various types of MRI contrast and a broad portfolio stems Contrast Media across CT/X-ray and MRI modalities, and own the EU standard manufacturing facilities.

Types of Contrast Media in Bei LuPharma

MRI CONTRAST MEDIA

Magnetic Resonance Imaging (MRI)Contrast Media is Gadolinium based contrast agent(GBCA). It is an intravenous injection, mainly used to enhance the image quality of internal organs, blood vessels and tissues during MRI examinations. GBCA contains gadolinium, which is connected to each other through carrier molecules to form a chelating agent. According to the different chemical structures, this contrast medium can be divided into two categories: linear and macrocyclic. The linear structure of the imaging agents is easier to release gadolinium ions, and the macrocyclic structure of the contrast material is more stable and less likely to release gadolinium ions.

CT/X-RAY CONTRAST MEDIA

Iodine-containing Contrast Media is one of the common imaging contrast agents used in radiology diagnosis and interventional therapy. It is also a basic diagnosis drug for cardiovascular imaging under X-ray. Currently, the iodinated Contrast Media used for cardiovascular system CT and digital subtraction angiography are all water-soluble organic iodinated contrast materials.

Finished Types of Contrast Media

	Product name	Characteristic	Specification
1	Gadopentetate Dimeglumine Injection	Injectable solution	469mg/ml: 10ml, 12ml, 15ml, 20ml
2	Gadobutrol Injection	Injectable solution
3	Ammonium iron citrate	Oral granules	3g：0.6g（Fe 129mg） 6g：1.2g（Fe 258mg）
4	Iopamidol Injection	Injectable solution	300mgI/ml: 50ml, 100ml 370mgI/ml: 50ml, 100ml
5	Iodixanol Injection	Injectable solution	270mgI/ml: 100ml 320mgI/ml: 50ml, 100ml
6	Iohexol Injection	Injectable solution	300mgI/ml: 20ml,50ml,75ml, 100ml 350mgI/ml: 20ml, 50ml, 100ml

API

	Products	CAS NO.	Packings	Classification
1	lohexol	66108-95-0	25Kg/Drum	API
2	lodixanol	92339-11-2	25Kg/Drum	API
3	lopromide	73334-07-3	25Kg/Drum	API
4	lopamidol	60166-93-0	25Kg/Drum	API
5	loversol	87771-40-2	25Kg/Drum	API
6	Gadobutrol		25Kg/Drum	API
7	Gadoterate Meglumine	92943-93-6	15Kg/Drum	API
8	Gadopentetate Monomeglumine	92923-57-4	25Kg/Drum	API
9	Gadopentetate Dimeglumine	86050-77-3	25Kg/Drum	API
10	Repaglinide		10Kg/Drum	API
11	Anhydrous Sodium Sulfate	7757-82-6	25Kg/Drum	API

Comparison of physicochemical characteristics of commonly used Contrast Media

Contrast media

(Concentration：mg（I）/ml)

Osmotic pressure

(mOsm/kg water）

Viscosity

（cP，37℃）

Iopamidol 300

616

Ioverol 300

651

Iohexol 300

672

Iobitridol 300

695

6

Iodixanol 320

290

The osmotic pressure of normal people is about 290-300mOsm/kg.

Taking the viscosity of water as 1, when the temperature is 37℃, the relative viscosity of whole blood is 4-5, and the relative viscosity of plasma is 1.6-2.4.

Three factors of renal injury induced by Contrast Media: Osmotic pressure, Viscosity and the total iodine. Reduced iodine intake is a feasible strategy to avoid kidney damage.

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