L-Lysine monohydrochloride Supplier
Solubility ofL-Lysine monohydrochloride
Solubility is the most distinctive physical property of L-lysine monohydrochloride, and its high aqueous solubility is the primary reason for its industrial dominance over free L-lysine. All solubility data are at 25 °C (ambient temperature) unless specified:
- Water: Highly soluble— solubility of ~70 g/100 mL (free L-lysine: ~63 g/100 mL). Solubility increases with temperature (e.g., ~90 g/100 mL at 40 °C, ~110 g/100 mL at 60 °C). Dissolution is endothermic (a small temperature drop occurs during dissolution) and rapid, with no precipitation in dilute to concentrated aqueous solutions (up to 60% w/v).
- Aqueous polar solvents: Soluble in methanol (~1 g/100 mL) and ethanol (~0.1 g/100 mL); slightly soluble in propylene glycol and glycerol (common food/ pharmaceutical excipients).
- Non-polar organic solvents: Insoluble in acetone, ether, chloroform, benzene, and hexane— consistent with its ionic salt nature (zwitterion + Cl⁻) and high polarity.
- Buffer solutions: Soluble in all common aqueous buffers (phosphate, citrate, Tris-HCl) over a pH range of 2.0–12.0, with no precipitation or chemical reaction— suitable for biological and pharmaceutical assay formulation.
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