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Contrast Media Manufacturing Company

For the purpose of medical imaging, a certain substance is introduced into the human body to change the image contrast of local tissues of the body. This introduced substance is Contrast Media, also known as Contrast Agents. As the first Contrast Media manufacturer in China, Beijing pharmaceuticals, as one of the most professional contrast media manufacturing companies, launched the domestic MRI Contrast Media Gadopentetate Dimeglumine Injection in 1992, which broke the foreign products monopoly and filled the domestic gap. As a well-known contrast media company, we could provide various types of MRI contrast and a broad portfolio stems Contrast Media across CT/X-ray and MRI modalities, and own the EU standard manufacturing facilities.

Types of Contrast Media in Beilu Pharma

MRI CONTRAST MEDIA

MRIContrast Mediais Gadolinium based contrast agent(GBCA). It is an intravenous injection, mainly used to enhance the image quality of internal organs, blood vessels and tissues during MRI examinations. GBCA contains gadolinium, which is connected to each other through carrier molecules to form a chelating agent. According to the different chemical structures, this contrast mediumcan be divided into two categories: linear and macrocyclic. The linear structure of the imaging agents is easier to release gadolinium ions, and the macrocyclic structure of the contrast material is more stable and less likely to release gadolinium ions.

Gadopentetate Dimeglumine Injection/API

Gadobutrol Injection/API

Gadobenate Dimeglumine Injection

Ferric Ammonium Citrate Effervescent Granules

CT/X-RAY CONTRAST MEDIA

Iodine-containing Contrast Media is one of the common imaging contrast agents used in radiology diagnosis and interventional therapy. It is also a basic diagnosis drug for cardiovascular imaging under X-ray. Currently, the iodinated Contrast Media used for cardiovascular system CT and digital subtraction angiography are all water-soluble organic iodinated contrast materials.

Iohexol Injection

Iopamidol Injection

Iodixanol Injection

Our dedication to your requirements, providing a full range of Contrast Media products

Finished Types of Contrast Media

Product name

Characteristic

Specification

1

Gadopentetate Dimeglumine Injection

Injectable solution

469mg/ml: 10ml, 12ml, 15ml, 20ml

2

Gadobutrol Injection

Injectable solution

  1. 7.5ml

3

Ammonium iron citrate

Oral granules

3g:0.6g(Fe 129mg)

6g:1.2g(Fe 258mg)

4

Iopamidol Injection

Injectable solution

300mgI/ml: 50ml, 100ml

370mgI/ml: 50ml, 100ml

5

Iodixanol Injection

Injectable solution

270mgI/ml: 100ml

320mgI/ml: 50ml, 100ml

6

Iohexol Injection

Injectable solution

300mgI/ml: 20ml,50ml,75ml, 100ml

350mgI/ml: 20ml, 50ml, 100ml

API & Intermediates Types of Contrast Media

Products

CAS NO.

Packings

Classification

1

Iohexol

66108-95-0

25kg

Contrast agent

2

Iodixanol

92339-11-2

25kg

Contrast agent

3

Iopromide

73334-07-3

25kg

Contrast agent

4

Iopamidol

60166-93-0

25kg

Contrast agent

5

Ioversol

87771-40-2

25kg

Contrast agent

6

Gadopentetate Monomeglumine

92923-57-4

25kg

Contrast agent

7

Gadopentetate Dimeglumine

86050-77-3

25kg

Contrast agent

8

Gadobutrol

25kg

Contrast agent

9

Calcobutrol

2kg

Excipients

10

Repaglinide

10kg

Anti-diabetic

11

Diethylenetriaminepentaacetic acid ( Pentaacetic Acid)(DTPA)

67-43-6

Intermediates

12

Iopamidol Intermediate (order based) 5-Amino-2,4,6-triiodoisophthalic acid

35453-19-1

25kg

Intermediates

Comparison of physicochemical characteristics of commonly used Contrast Media

Contrast media

Osmotic pressure

Viscosity

(Concentration:mg(I)/ml)

(mOsm/kg water)

(cP, 37℃)

Iopamidol 300

616

Ioverol 300

651

Iohexol 300

672

Iobitridol 300

695

6

Iodixanol 320

290

The osmotic pressure of normal people is about 290-300mOsm/kg.

Taking the viscosity of water as 1, when the temperature is 37℃, the relative viscosity of whole blood is 4-5, and the relative viscosity of plasma is 1.6-2.4.

Three factors of renal injury induced by Contrast Media: Osmotic pressure, Viscosity and the total iodine. Reduced iodine intake is a feasible strategy to avoid kidney damage.



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Iopamidol Injection
Iopamidol Injection IopamidolInjection is the second-generation non-ionic iodinated Contrast Media launched in the global market. In 2015, Beilu firstly launched and l...
CT/X-Ray Contrast Media
CT/X-Ray Contrast Media The main component of CT/X-ray Contrast Media is iodine. The Iodinated Contrast Media is a colorless, transparent, slightly viscous liquid. At pres...
Contrast Media Manufacturing Company
Contrast Media Manufacturing Company For the purpose of medical imaging, a certain substance is introduced into the human body to change the image contrast of local tissues of the body...
Gadobutrol Injection/API
Gadobutrol Injection/API In 2020, Beilu launched its macrocyclic Contrast Media- Gadobutrol Injection, it is gadolinium-based non-ionic Contrast Media, a paramagnetic Contr...
Iodixanol Injection
Iodixanol Injection IodixanolInjection is a Contrast Media that is isotonic with plasma. It has excellent cardiac safety and renal safety, which is most comfortable to...
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