Contrast Media Manufacturing Company
For the purpose of medical imaging, a certain substance is introduced into the human body to change the image contrast of local tissues of the body. This introduced substance is Contrast Media, also known as Contrast Agents. As the first Contrast Media manufacturerin China, Beilu Pharma launched the domestic MRI Contrast Media Gadopentetate Dimeglumine Injection in 1992, which broke the foreign products monopoly and filled the domestic gap. As a well-known contrast media manufacturing companies, we could provide a broad portfolio stems Contrast Media across CT/X-ray and MRI modalities, and own the EU standard manufacturing facilities.
Types of Contrast Media in Beilu Pharma
Magnetic Resonance Imaging (MRI)Contrast Media is Gadolinium based contrast agent(GBCA). It is an intravenous injection, mainly used to enhance the image quality of internal organs, blood vessels and tissues during MRI examinations. GBCA contains gadolinium, which is connected to each other through carrier molecules to form a chelating agent. According to the different chemical structures, this contrast medium can be divided into two categories: linear and macrocyclic. The linear structure of the imaging agents is easier to release gadolinium ions, and the macrocyclic structure of the contrast material is more stable and less likely to release gadolinium ions.
CT/X-RAY CONTRAST MEDIA
Iodine-containing Contrast Media is one of the common imaging contrast agents used in radiology diagnosis and interventional therapy. It is also a basic diagnosis drug for cardiovascular imaging under X-ray. Currently, the iodinated Contrast Media used for cardiovascular system CT and digital subtraction angiography are all water-soluble organic iodinated contrast materials.
Finished Types of Contrast Media
|
Product name |
Characteristic |
Specification |
|
|
1 |
Gadopentetate Dimeglumine Injection |
Injectable solution |
469mg/ml: 10ml, 12ml, 15ml, 20ml |
|
2 |
Gadobutrol Injection |
Injectable solution |
|
|
3 |
Ammonium iron citrate |
Oral granules |
3g：0.6g（Fe 129mg） 6g：1.2g（Fe 258mg） |
|
4 |
Iopamidol Injection |
Injectable solution |
300mgI/ml: 50ml, 100ml 370mgI/ml: 50ml, 100ml |
|
5 |
Iodixanol Injection |
Injectable solution |
270mgI/ml: 100ml 320mgI/ml: 50ml, 100ml |
|
6 |
Iohexol Injection |
Injectable solution |
300mgI/ml: 20ml,50ml,75ml, 100ml 350mgI/ml: 20ml, 50ml, 100ml |
API & Intermediates Types of Contrast Media
|
Products |
CAS NO. |
Packings |
Classification |
|
|
1 |
Iohexol |
66108-95-0 |
25kg |
Contrast agent |
|
2 |
Iodixanol |
92339-11-2 |
25kg |
Contrast agent |
|
3 |
Iopromide |
73334-07-3 |
25kg |
Contrast agent |
|
4 |
Iopamidol |
60166-93-0 |
25kg |
Contrast agent |
|
5 |
Ioversol |
87771-40-2 |
25kg |
Contrast agent |
|
6 |
Gadopentetate Monomeglumine |
92923-57-4 |
25kg |
Contrast agent |
|
7 |
Gadopentetate Dimeglumine |
86050-77-3 |
25kg |
Contrast agent |
|
8 |
Gadobutrol |
25kg |
Contrast agent |
|
|
9 |
Calcobutrol |
2kg |
Excipients |
|
|
10 |
Repaglinide |
10kg |
Anti-diabetic |
|
|
11 |
Diethylenetriaminepentaacetic acid ( Pentaacetic Acid)（DTPA） |
67-43-6 |
Intermediates |
|
|
12 |
Iopamidol Intermediate (order based) 5-Amino-2,4,6-triiodoisophthalic acid |
35453-19-1 |
25kg |
Intermediates |
Comparison of physicochemical characteristics of commonly used Contrast Media
|
Contrast media (Concentration：mg（I）/ml) |
Osmotic pressure (mOsm/kg water） |
Viscosity （cP，37℃） |
|
Iopamidol 300 |
616 |
|
|
Ioverol 300 |
651 |
|
|
Iohexol 300 |
672 |
|
|
Iobitridol 300 |
695 |
6 |
|
Iodixanol 320 |
290 |
The osmotic pressure of normal people is about 290-300mOsm/kg.
以水的粘度为1，当温度为37℃时，全血的相对粘度为4-5，血浆的相对粘度为1.6-2.4。
造影剂引起肾损伤的三个因素：渗透压、粘度和总碘。减少碘摄入量是避免肾脏损害的可行策略。
北路是一家专业的，我们提供ct造影剂、mri造影剂、等。想了解更多？请联系我们。
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