Bivalirudin Trifluoroacetate
|
Product Name |
Bivalirudin Trifluoroacetate |
|
Sequence |
D-Phe-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-OH |
|
Cas No. |
|
|
Molecular Formula |
C98H138N24O33 |
|
Molecular Weight |
2180.33 |
|
Purity (HPLC) |
98.0%min. |
|
Appearance |
White Powder |
|
Single Impurity (HPLC) |
1.0%max |
|
Amino Acid Composition |
±10% of theoretical |
|
Peptide Content (N%) |
≥80.0% |
|
Water Content (Karl Fischer) |
≤8.0% |
|
TrifluoroAcetate Content(HPIC) |
≤12.0% |
|
MS (ESI) |
Consistent |
|
Mass Balance |
95.0~105.0% |
2. Description:
Bivalirudin (Angiomax or Angiox, manufactured by The Medicines Company) is a specific and reversible direct thrombin inhibitor (DTI).
Bivalirudin is a DTI that overcomes many limitations seen with indirect thrombin inhibitors, such as heparin. Bivalirudin is a short, synthetic peptide that is potent, highly specific, and a reversible inhibitor of thrombin. It inhibits both circulating and clot-bound thrombin, while also inhibiting thrombin-mediated platelet activation and aggregation. Bivalirudin has a quick onset of action and a short half-life. It does not bind to plasma proteins (other than thrombin) or to red blood cells. Therefore it has a predictable antithrombotic response. There is no risk for Heparin Induced Thrombocytopenia/Heparin Induced Thrombosis-Thrombocytopenia Syndrome (HIT/HITTS). It does not require a binding cofactor such as antithrombin and does not activate platelets. These characteristics make bivalirudin an ideal alternative to heparin.
Bivalirudin clinical studies demonstrated consistent positive outcomes in patients with stable angina, unstable angina (UA), non-ST segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STEMI) undergoing PCI in 7 major randomized trials.
Отправить запрос, связаться с поставщиком
Другие товары поставщика
 |
Boldenone Undecylenate | Boldenone Undecylenate CAS NO.: 13103-34-9 Molecular Formula: C30H44O3 Molecular weight: 452.67 Assay: 97.0~103.0% Standard: Enterprise Standard B... |
 |
Finasteride | Quick Detail 1 ) Finasteride 2 ) Alias: Proscar 3 ) CAS No: 98319-26-7 4 ) MF: C23H36N2O2 5 ) MW: 372.55 6 ) Purity: 98.5% 7 ) Appearance: whi... |
 |
Stanolone | Stanolone Chemical Name: 5alpha-androstan-17?-ol-3-one CAS No.: 521-18-6 Chemical Formula: C19H30O2 Description: white crystalline powder Specifica... |
 |
Oxandrolone | Detail Oxandrolone Chemical Name: 5alpha-androstan-2-oxa-17alpha-methyl-17beta-ol-3-one CAS NO.: 53-39-4 Molecular Formula: C19H30O3 Mo... |
 |
Nandrolone phenylpropionate | Nandrolone phenylpropionate Chemical Name: 4-estren-17beta-ol-3-one phenylpropionate CAS NO.: 62-90-8 Molecular Formula: C27H34O3 Molecular weight:... |
Похожие товары
 |
C500-1.7 Series High Flow Multi-Stage Centrifugal Blower /Centrifugal Blower | Продавец: Greentech International (Zhangqiu) Co., Ltd | Greentech International (Zhangqiu) Co., Ltdis the professional blower supplier.Multistage Centrif... |
 |
Common Rail injector control valve F00VC01303 | Продавец: China Lutong Part Plant | Common Rail injector control valve F00VC01303 Tina#Stainless Steel Cylindrical Pin##Denso Common... |
 |
Common Rail injector control valve F00VC01200 | Продавец: China Lutong Part Plant | Common Rail injector control valve F00VC01200 Tina#Stainless Steel Cylindrical Pin##Denso Common... |
 |
Injector Control Valve Plate 24# | Продавец: China Lutong Part Plant | Injector Control Valve Plate 24# Tina#Stainless Steel Cylindrical Pin##Denso Common Rail Injecto... |
 |
Injector Control Valve Plate 12# | Продавец: China Lutong Part Plant | Injector Control Valve Plate 12# Tina#Stainless Steel Cylindrical Pin##Denso Common Rail Injecto... |
