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CAS No. Fumarate Vonoprazan

CAS No. Fumarate Vonoprazan

Vonoprazan Fumarate(TAK-438 CAS No., a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan Fumarate inhibits H+, K+-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan fumarate fda approvalis developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease.

Synonym

Vonaprazan fumarate; 5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine2-butenedioate(Vonoprazan); 1-[5-(2-fluorophenyl)-1-pyridin-3-Chemicalbookylsulfonylpyrrol-3-yl]-N-methylmethanamine; AK-438; Vonaprazan(TAK-438); vonoprazan(tak-438); Vonoprazanfumarate(TAK-438); vonoprazan(tak

CAS No.: 1260141 27 2

EC No.: 250-635-4

MF: C21H20FN3O6S

MW: 461.46

Parameters of Fumarate Vonoprazan, TAK-438

Item

Specification

Results

Appearance

Off-white To White Crystalline Powder

White Crystalline Powder

Solubility

Soluble In Dmso, Slightly Soluble In Methanol, Water, Very Slightly Soluble In Alcohol.

Complies

Identification

1HNMR

Complies

Melting Point

196-201℃

198-199℃

Residue On Ignition

Water

Single Impurity

Total Impurities

Heavy Metals

NMT20PPM

Complies

Assay

Packing:

100g/bag; 500g/bag; 1kg/bag; 25kg/drum

Recommended storage method:

Store in a cool, dry and ventilated place.

Recommended storage temperature:

2 - 8 °C

Product usage:

Antigastric drugs

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