CAS No. Fumarate Vonoprazan
CAS No. Fumarate Vonoprazan
Vonoprazan Fumarate(TAK-438 CAS No., a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan Fumarate inhibits H+, K+-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan fumarate fda approvalis developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease.
Synonym
Vonaprazan fumarate; 5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine2-butenedioate(Vonoprazan); 1-[5-(2-fluorophenyl)-1-pyridin-3-Chemicalbookylsulfonylpyrrol-3-yl]-N-methylmethanamine; AK-438; Vonaprazan(TAK-438); vonoprazan(tak-438); Vonoprazanfumarate(TAK-438); vonoprazan(tak
CAS No.: 1260141 27 2
EC No.: 250-635-4
MF: C21H20FN3O6S
MW: 461.46
Parameters of Fumarate Vonoprazan, TAK-438
|
Item |
Specification |
Results |
|
Appearance |
Off-white To White Crystalline Powder |
White Crystalline Powder |
|
Solubility |
Soluble In Dmso, Slightly Soluble In Methanol, Water, Very Slightly Soluble In Alcohol. |
Complies |
|
Identification |
1HNMR |
Complies |
|
Melting Point |
196-201℃ |
198-199℃ |
|
Residue On Ignition |
||
|
Water |
||
|
Single Impurity |
||
|
Total Impurities |
||
|
Heavy Metals |
NMT20PPM |
Complies |
|
Assay |
Packing:
100g/bag; 500g/bag; 1kg/bag; 25kg/drum
Recommended storage method:
Store in a cool, dry and ventilated place.
Recommended storage temperature:
2 - 8 °C
Product usage:
Antigastric drugs
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