Thyroid Peroxidase (TPO)

• 

Thy peroxidase(TPO), also called thyroperoxidase or thyroid peroxidase igg, catalyzes the iodization of thyroglobulin tyrosine during the biosynthesis of T3 and T4.

TPO is an enzyme expressed mainly in the thyroid, where it is secret into the colloid.

The increased TPO level may reflect the promoted thyroid hormone synthesis, which may cause hyperthyroidism.

The detection of TPO helps with diagnosing Hashimoto's disease (HD) and autoimmune hyperthyroidism; Toxic chronic goiter (Graves); Monitoring the effect of immunotherapy; To detect the possibility of familial thyroid disease; Prediction of postpartum thyroid dysfunction in pregnant women.

SEKBIO provides Humanised anti-human TPO mAb for diagnosis usage.

Thyroid Peroxidase Intro

Thyroid peroxidase(TPO) TPO is an important enzyme that catalyzes thyroid hormones. TPO is synthesized by thyroid follicular cells. It is a 10% glycated hemoglobin-like protein composed of 933 amino acid residues with a molecular weight of 103 kD. It is most abundantly distributed in the microvilli on the follicular lumen surface. TPO uses hydrogen peroxide as an oxidant. TSH regulates the generation and activity of TPO. In the experiment, the action of TPO disappeared 48 hours after removing the rat pituitary, and TPO activity will restore after the injection of thyroid-stimulating hormone. Thiourea drugs can inhibit the activity of TPO, thus inhibiting the synthesis of thyroid hormones, and are commonly used clinically for the treatment of hyperthyroidism (hyperthyroidism).

Thyroid Peroxidase Antibody

Thyroid peroxidase (TPO) is a membrane-bound heme protein with a molecular weight of about 100,000. TPO participates in two different reactions in the biosynthesis of thyroid hormones. If thyroid peroxidase antibodies are present, it is a sign of concomitant damage to thyroid function or potential harm. Peroxidase antibody-positive suggests that the thyroid disease may be Hashimoto's thyroiditis.

Sekbioprovide thyroid antibodies tpo and tg, high tpo and tg antibodies, ivd antibodyand etc. want to anti thyroid peroxidase antibody test costor more, contact us.

Другие товары поставщика

	CA50 Tumor Marker	CA50 is a kind of sialic acid ester and sialic acid glycoprotein, which generally does not exist in normal tissues. When cells become malignant, gl...
	Prostate-Specific Antigen (PSA Tumor Marker)	Prostate-specific antigen （PSA specific antigen）, also known as gamma-selenoprotein or kallikrein-3, is a glycoprotein enzyme encoded in humans by ...
	Influenza (Flu)	Influenza virus is the representative species of the Orthomyxoviridae family. The typical clinical symptoms of these diseases are acute high fever,...
	Testosterone (Testo)	Testosteroneis the primary male sex hormone and an anabolic steroid. In male humans, testosterone plays a vital role in developing male reproductiv...
	C-Reaction Protein (CRP)	C-reactive protein (CRP) refers to several proteins (acute proteins) that rise sharply in blood plasma in response to infection or tissue damage. ...

Похожие товары

	Trimellitic anhydride 97%	Продавец: Yufeng International Group Co., Ltd	Trimellitic anhydrideis a 2-benzofuran compound having oxo groups at the 1- and 3-positions and a...
	Isobutyric Anhydride CAS 97-72-3	Продавец: Yufeng International Group Co., Ltd	Product Name: Isobutyric Anhydride CAS No.: 97-72-3 Purity: 99% Molecular Formula: C6H10O3 Mo...
	Isobutyric Acid CAS 79-31-2	Продавец: Yufeng International Group Co., Ltd	Product Name:ISOBUTYRIC ACID Synonyms: 2-Methylpropanoic acid 79-31-2 Isobutanoic acid 2-Met...
	2-Amino-2-methyl-1-propanol（AMP）CAS：124-68-5	Продавец: Yufeng International Group Co., Ltd	AtYufeng, a trusted 2-Amino-2-methyl-1-propanol Factory & Supplier, we prioritize quality and...
	Dimethyl sulfoxide (DMSO) CAS: 67-68-5	Продавец: Yufeng International Group Co., Ltd	Yufengis one of the leading dimethyl sulfoxide suppliers and also a professional such manufacture...