Natamycin

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Natamycin is a natural antifungal agent and antibiotic that belongs to the polyene macrolide group. It is produced through fermentation by certain species of *Streptomyces*, such as *Streptomyces natalensis*. Natamycin has both medical and food applications due to its ability to inhibit the growth of fungi, including yeasts and molds.
Key Features and Uses:
1. Food Preservation:
·Natamycin is widely used in the food industry as a natural preservative, particularly for dairy products like cheese and yogurt.
·It prevents spoilage caused by fungi without affecting bacterial cultures, making it ideal for fermented foods.
·It is applied to the surface of foods or incorporated into packaging to extend shelf life.
2. Medical Applications:
·Natamycin is used to treat fungal infections, particularly those of the skin, eyes, and mucous membranes.
·It is commonly prescribed as an eye drop for fungal keratitis, a fungal infection of the cornea.
·Unlike some antifungals, natamycin is effective at low concentrations and has minimal systemic absorption when applied topically.
3. Mechanism of Action:
·Natamycin binds to ergosterol, a key component of fungal cell membranes, disrupting membrane integrity and inhibiting fungal growth.
·It does not act on bacteria, making it selective for fungal pathogens.
4. Safety:
·Natamycin is considered safe for human consumption and is approved by regulatory agencies like the FDA and EFSA (European Food Safety Authority).
·It is non-toxic when used at recommended concentrations in food or topical medications.

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