Nisin

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Nisin’s stability is significantly affected by interactions with food components, which alter its free concentration and ability to reach bacterial targets—directly impacting antimicrobial performance.
Protein/fat binding: In high-protein (e.g., meat, dairy) or high-fat (e.g., cheese, salad dressings) foods, nisin binds to proteins (e.g., casein) or fat globules via hydrophobic and electrostatic interactions. This reduces the free nisin concentration available to act on bacteria, weakening efficacy. For example, in full-fat milk, the effective free nisin concentration is 30–40% lower than in skim milk, requiring a 10–20% higher addition level to achieve the same antimicrobial effect.
Ion-induced stabilization/inactivation: Divalent cations (Ca²⁺, Mg²⁺) stabilize nisin’s structure by forming complexes with its carboxyl groups, enhancing heat resistance and extending activity retention. Conversely, transition metals (Fe³⁺, Cu²⁺) or reducing agents (e.g., mercaptoethanol) catalyze oxidative degradation or cross-link cleavage, reducing efficacy. Compounding nisin with EDTA (a chelating agent) mitigates metal ion-induced inactivation, preserving antimicrobial activity.
Sugar/preservative interactions: High sugar concentrations (e.g., in syrups or confectionery) may reduce nisin solubility and diffusion, slightly lowering efficacy. However, nisin exhibits synergistic stability with organic acids (e.g., lactic acid) and plant extracts (e.g., tea polyphenols), which not only enhance its stability but also broaden its antimicrobial spectrum (e.g., inhibiting Gram-negative bacteria when combined with EDTA).

Другие товары поставщика

	Nisin 500g/1Kg/25Kg	Nisin, also known as lactococcin or transliterated as "Nisin," is a widely used natural antimicrobial peptide. Below is a detailed product introduc...
	Nisin Raw Material 1kg	Nisin is generally safe for long-term use, with minimal side effects: Common side effects: Mild GI discomfort (e.g., bloating, gas) in <5% of us...
	Nisin	Fundamental Properties of NisinSource: Biosynthesized by Lactococcus lactis during fermentation (e.g., in the production of cheese or fermented mil...
	Nisin Supplier	Solubility: Nisin's solubility varies with pH. For example: In water (pH = 7), its solubility is 49.0 mg/ml In 0.02M hydrochloric acid, its solubil...
	Nisin Price 500g/1Kg/25Kg	By effectively inhibiting the growth of spoilage bacteria and pathogens, nisin significantly prolongs the shelf life of food products, particularly...

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