Aminomethyl Resin

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4-Hydroxymethyl-phenylacetamidomethyl resin

PAM resin has become the most widely used resin in Boc chemistry peptide synthesis. It has greater acid stability than Merrifield resin, making it suitable for synthesizing medium and large peptides, such as DNA binding polyamines, human matrix Gla protein(MGP), Kappa-casein. The first carboxylic acid is attached to PAM resinusing an activating agent such as DCC and DMAP. These conditions can lead to partial epimerization of the amino acids, so HOBt is normally added to reduce racemization.

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