.

Thyroid Stimulating Hormone Receptor (TSHR)

The TSH receptor is a member of the G protein-coupled receptor superfamily of integral membrane proteins.

The thyrotropin receptor (or TSH receptor) locates primarily in the body of the thyroid gland. It recognizes and binds to stimulating thyroid hormone (also known as "thyrotropin") secreted from the pituitary gland.

TSH stimulates the production of thyroxine (T4) and triiodothyronine (T3).

TSHR is closely related to the pathogenesis of various autoimmune thyroid diseases and is an essential indicator for the clinical diagnosis of these diseases.

SEKBIO is now offering Mouse anti-human TSHR mAb, Humanized anti-human TSHR mAb, Recombinant human sTSHR (Soluble), and human TSHR extractive of cell membranes (Full length) for diagnosis usage.

TSHR

Thyroid-stimulating hormone receptor (TSHR) and its homologous luteinizing hormone/chorionic gonadotropin receptor and follicle-stimulating hormone receptor belong to a class of glycoprotein receptors. They are also visual A member of the large family of G protein-coupled receptors (GPcRs) of rhodopsin (approximately 45% identity at the amino acid level). TSHR is mainly expressed in thyroid follicular cells and activates the protein kinase A (PKA) and phospholipase C (Phospholipases C, PLc) signal transduction systems after combining with thyroid-stimulating hormone (TSH) under physiological conditions. , regulate the growth and differentiation of the thyroid, and promote the synthesis and release of thyroid hormones.

Anti TSH Antibody

The expression of TSHR can also be found in other cells or tissues, including adipocytes, fibroblasts, osteoblasts and osteoclasts, bone marrow cells and cardiomyocytes, etc., and is expressed in embryonic stem cells at an early stage. In autoimmune thyroid diseases, especially toxic diffuse goiter (Graves' disease, GD), TSHR can act as an autoantigen and bind to thyroid-stimulating antibody (TSAb) to produce TSH-like stimulation. The reaction will eventually lead to the loss of thyroid autoimmune tolerance, production and release of excessive thyroid hormones, and clinical manifestations of hyperthyroidism such as palpitations, sweating, and hyperthyroidism. Therefore, studying the structure of thyroid-stimulating hormone receptors and elucidating the interaction between autoantibodies and thyroid-stimulating hormone receptor (TSHR) molecules is vital for understanding Graves disease's pathogenesis, a common organ-specific autoimmune disease, and guiding clinical practice. Diagnosis and treatment have far-reaching significance.

Sekbioprovide tshr thyroid, tsh receptor test, tsh blocking antibodies, tsh stimulating antibodies, tsh stimulating immunoglobulin, thyroid stimulating immunoglobulin and tsh receptor antibodies, tshr test, ivd antigenand etc. want to know tshr normal rangeor more, contact us.



Send product request

To: Shenzhen SEKBIO Co., Ltd
Your E-mail:
Message text:


Send to other suppliers

Other supplier products

Testosterone (Testo)
Testosterone (Testo) Testosterone (Testo) Testosteroneis the primary male sex hormone and an anabolic steroid. In male humans, male testosteroneplays a vital role in d...
CA50 Tumor Marker
CA50 Tumor Marker CA50 is a kind of sialic acid ester and sialic acid glycoprotein, which generally does not exist in normal tissues. When cells become malignant, gl...
Thyroglobulin (Tg)
Thyroglobulin (Tg) Thyroglobulin (Tg) Thyroid thyroglobulinis a 660 kDa, a dimeric glycoprotein produced by the follicular cells of the thyroid and released into the...
Cardiac Troponin I (cTnI)
Cardiac Troponin I (cTnI) Cardiac troponin I, often denoted as cTnI, is presented in cardiac muscle tissue by a single isoform with a molecular weight of 23.9 kDa. Cardiac t...
Tumor Marker
Tumor Marker A ca tumour markeris a chemical substance that reflects the presence of a Tumor. It is present in malignant tumour cells, not in normal adult tissu...
All supplier products

Same products

LUBE SH-ONE-4S 400G for Fanuc Machines
LUBE SH-ONE-4S 400G for Fanuc Machines Seller: Guangdong Juguangheng Automation Equipment Co.,Ltd. Lubecorp part number 249250 is a 400ml bellows style cartridge often times used in autolube appli...
Mobil Grease 28 Synthetic Aviation Grease
Mobil Grease 28 Synthetic Aviation Grease Seller: Guangdong Juguangheng Automation Equipment Co.,Ltd. Mobil grease 28is a high performance, antiwear grease. Available as a cartridge,2kgcan, 16kg pail...
Kluber Isoflex Topas NCA 5051 50ml  Original Lubricants
Kluber Isoflex Topas NCA 5051 50ml Original Lubricants Seller: Guangdong Juguangheng Automation Equipment Co.,Ltd. ISOFLEX TOPAS NCA 5051is a beige synthetic long homogeneous and short fiber. It consists of a syn...
CHRISTO-LUBE MCG 111 2-OZ Valve Seal Grease
CHRISTO-LUBE MCG 111 2-OZ Valve Seal Grease Seller: Guangdong Juguangheng Automation Equipment Co.,Ltd. Christo-Lube®MCG 111is a fully fluorinated grease thickened with PTFE which operates under ex...
Permatex 81160 85G High Temperature Resistant Resin
Permatex 81160 85G High Temperature Resistant Resin Seller: Guangdong Juguangheng Automation Equipment Co.,Ltd. Permatex 81160 High-Temp Red RTV Silicone Gasket, 3 oz