Thyroid Stimulating Hormone Receptor (TSHR)

• 

The TSH receptor is a member of the G protein-coupled receptor superfamily of integral membrane proteins.

The thyrotropin receptor (or TSH receptor) locates primarily in the body of the thyroid gland. It recognizes and binds to stimulating thyroid hormone (also known as "thyrotropin") secreted from the pituitary gland.

TSH stimulates the production of thyroxine (T4) and triiodothyronine (T3).

TSHR is closely related to the pathogenesis of various autoimmune thyroid diseases and is an essential indicator for the clinical diagnosis of these diseases.

SEKBIO is now offering Mouse anti-human TSHR mAb, Humanized anti-human TSHR mAb, Recombinant human sTSHR (Soluble), and human TSHR extractive of cell membranes (Full length) for diagnosis usage.

TSHR

Thyroid-stimulating hormone receptor (TSHR) and its homologous luteinizing hormone/chorionic gonadotropin receptor and follicle-stimulating hormone receptor belong to a class of glycoprotein receptors. They are also visual A member of the large family of G protein-coupled receptors (GPcRs) of rhodopsin (approximately 45% identity at the amino acid level). TSHR is mainly expressed in thyroid follicular cells and activates the protein kinase A (PKA) and phospholipase C (Phospholipases C, PLc) signal transduction systems after combining with thyroid-stimulating hormone (TSH) under physiological conditions. , regulate the growth and differentiation of the thyroid, and promote the synthesis and release of thyroid hormones.

Anti TSH Antibody

The expression of TSHR can also be found in other cells or tissues, including adipocytes, fibroblasts, osteoblasts and osteoclasts, bone marrow cells and cardiomyocytes, etc., and is expressed in embryonic stem cells at an early stage. In autoimmune thyroid diseases, especially toxic diffuse goiter (Graves' disease, GD), TSHR can act as an autoantigen and bind to thyroid-stimulating antibody (TSAb) to produce TSH-like stimulation. The reaction will eventually lead to the loss of thyroid autoimmune tolerance, production and release of excessive thyroid hormones, and clinical manifestations of hyperthyroidism such as palpitations, sweating, and hyperthyroidism. Therefore, studying the structure of thyroid-stimulating hormone receptors and elucidating the interaction between autoantibodies and thyroid-stimulating hormone receptor (TSHR) molecules is vital for understanding Graves disease's pathogenesis, a common organ-specific autoimmune disease, and guiding clinical practice. Diagnosis and treatment have far-reaching significance.

Sekbioprovide tshr thyroid, tsh receptor test, tsh blocking antibodies, tsh stimulating antibodies, tsh stimulating immunoglobulin, thyroid stimulating immunoglobulin and tsh receptor antibodies, tshr test, ivd antigenand etc. want to know tshr normal rangeor more, contact us.

Другие товары поставщика

	Heterophilic Blocking Reagent	Heterophilic antibodies refer to antibodies that have two or more different antibody structures. Usually, heterophilic antibodies are produced by t...
	Cardiac Troponin I (cTnI)	Cardiac troponin I, often denoted as cTnI, is presented in cardiac muscle tissue by a single isoform with a molecular weight of 23.9 kDa. Cardiac t...
	Testosterone (Testo)	Testosteroneis the primary male sex hormone and an anabolic steroid. In male humans, testosterone plays a vital role in developing male reproductiv...
	Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA II Tumor Marker)	In the absence of vitamin K, liver cells cannot depend on vitamin K in the synthesis of standard clotting factors, only the synthesis of no functio...
	25-OH Vitamin D	25OH Vitamin D Vitamin D is converted to 25-hydroxyvitamin D (25OHD) by hydroxylation in the liver and the active 1, 25-dihydroxy vitamin D in the...

Похожие товары

	MOBILUX EP 0 16KG Lithium Complex Grease	Продавец: Guangdong Juguangheng Automation Equipment Co.,Ltd.	This extreme pressure Grease has an NLGI Grade0comes in a 5-gallon bucket and weighs 38.53lbs. It...
	Nisin	Продавец: Hebei Shengxue Dacheng Pharmaceutical Co., Ltd.	Nisin, a natural antimicrobial peptide, has various applications in the food industry due to its ...
	Nisin	Продавец: Hebei Shengxue Dacheng Pharmaceutical Co., Ltd.	Nisin is considered a natural preservative because it is derived from the fermentation of bacteri...
	Nisin	Продавец: Hebei Shengxue Dacheng Pharmaceutical Co., Ltd.	Nisin is a natural antimicrobial peptide produced by certain strains of the bacterium Lactococcus...
	Nisin Quality Manufacturer	Продавец: Hebei Shengxue Dacheng Pharmaceutical Co., Ltd.	In some cases, the addition of nisin allows dairy products to be preserved without the need for e...