Thyroid Stimulating Hormone Receptor (TSHR)
The TSH receptor is a member of the G protein-coupled receptor superfamily of integral membrane proteins.
The thyrotropin receptor (or TSH receptor) locates primarily in the body of the thyroid gland. It recognizes and binds to stimulating thyroid hormone (also known as "thyrotropin") secreted from the pituitary gland.
TSH stimulates the production of thyroxine (T4) and triiodothyronine (T3).
TSHR is closely related to the pathogenesis of various autoimmune thyroid diseases and is an essential indicator for the clinical diagnosis of these diseases.
SEKBIO is now offering Mouse anti-human TSHR mAb, Humanized anti-human TSHR mAb, Recombinant human sTSHR (Soluble), and human TSHR extractive of cell membranes (Full length) for diagnosis usage.
TSHR
Thyroid-stimulating hormone receptor (TSHR) and its homologous luteinizing hormone/chorionic gonadotropin receptor and follicle-stimulating hormone receptor belong to a class of glycoprotein receptors. They are also visual A member of the large family of G protein-coupled receptors (GPcRs) of rhodopsin (approximately 45% identity at the amino acid level). TSHR is mainly expressed in thyroid follicular cells and activates the protein kinase A (PKA) and phospholipase C (Phospholipases C, PLc) signal transduction systems after combining with thyroid-stimulating hormone (TSH) under physiological conditions. , regulate the growth and differentiation of the thyroid, and promote the synthesis and release of thyroid hormones.
Anti TSH Antibody
The expression of TSHR can also be found in other cells or tissues, including adipocytes, fibroblasts, osteoblasts and osteoclasts, bone marrow cells and cardiomyocytes, etc., and is expressed in embryonic stem cells at an early stage. In autoimmune thyroid diseases, especially toxic diffuse goiter (Graves' disease, GD), TSHR can act as an autoantigen and bind to thyroid-stimulating antibody (TSAb) to produce TSH-like stimulation. The reaction will eventually lead to the loss of thyroid autoimmune tolerance, production and release of excessive thyroid hormones, and clinical manifestations of hyperthyroidism such as palpitations, sweating, and hyperthyroidism. Therefore, studying the structure of thyroid-stimulating hormone receptors and elucidating the interaction between autoantibodies and thyroid-stimulating hormone receptor (TSHR) molecules is vital for understanding Graves disease's pathogenesis, a common organ-specific autoimmune disease, and guiding clinical practice. Diagnosis and treatment have far-reaching significance.
Sekbioprovide tshr thyroid, tsh receptor test, tsh blocking antibodies, tsh stimulating antibodies, tsh stimulating immunoglobulin, thyroid stimulating immunoglobulin and tsh receptor antibodies, tshr test, ivd antigenand etc. want to know tshr normal rangeor more, contact us.
在线联系供应商
Other supplier products
 |
CA50 Tumor Marker | CA50 is a kind of sialic acid ester and sialic acid glycoprotein, which generally does not exist in normal tissues. When cells become malignant, gl... |
 |
CA242 Tumor Marker | CA242, or Cancer Antigen 242, is a notable glycoprotein biomarker within the realm of oncology and the biomedical industry. It is classified as a m... |
 |
Triiodothyronine (T3) | Triiodothyronine, also known as T3, is a thyroid hormone. It affects almost every physiological process in the body, including growth and developme... |
 |
Inflammatory Marker | Inflammatory cytokines refer to various cytokines involved in the inflammatory response. And the inflammatory markers can identify the severity and... |
 |
Prostate-Specific Antigen (PSA Tumor Marker) | Prostate-specific antigen （PSA specific antigen）, also known as gamma-selenoprotein or kallikrein-3, is a glycoprotein enzyme encoded in humans by ... |
Same products
 |
蓝翠鸟威尼斯灰泥涂料 墙面艺术灰泥 奢华质感 | 卖方: 中山蓝翠鸟新型环保材料有限公司 | 产品概述 蓝翠鸟威尼斯灰泥是商业空间与艺术场馆优选的艺术涂装材料，以精选天然石膏、环保水性成膜物质为原料，肌理独特且富有层次感，耐擦洗、易维护，适配商业展厅墙面、艺术画廊展墙、高端餐厅主题墙面... |
 |
蓝翠鸟天鹅绒纹理漆 室内设计高级感墙面装饰漆 | 卖方: 中山蓝翠鸟新型环保材料有限公司 | 产品概述 这是一款为空间注入情绪的涂料。天鹅绒般柔和的哑光表面，拥有安抚视觉和心灵的效果，能自然营造出宁静、安全、包裹感的氛围。特别适用于打造家庭阅读角、私人工作室、瑜伽室或任何您需要放松... |
 |
蓝翠鸟 水包砂 | 高弹抗裂 外墙专用涂料 | 卖方: 中山蓝翠鸟新型环保材料有限公司 | 产品概述 蓝翠鸟高弹抗裂水包砂，专为应对墙体细微开裂问题而设计。其涂层具备优异的弹性与延展性，能有效桥接并遮盖基层微裂缝，适用于易产生温度应力或轻微沉降的建筑外墙，提供持久的完美外观。 ... |
 |
蓝翠鸟 简修天鹅绒覆盖漆 | 旧墙翻新神器 遮盖涂料 | 卖方: 中山蓝翠鸟新型环保材料有限公司 | 产品概述 厌倦了老旧的墙面？蓝翠鸟简修天鹅绒漆是您的快速翻新方案。它拥有超强的遮盖力和附着力，能直接覆盖大多数旧墙面（如乳胶漆、腻子层），简化施工步骤。快速赋予老旧空间全新的天鹅绒质感与现... |
 |
商业空间用瓷砖胶——高效施工、耐磨耐用 | 卖方: 中山蓝翠鸟新型环保材料有限公司 | 产品概述 瓷砖胶是适用于商场、酒店、写字楼等商业空间的专业粘结材料，以优质水泥、级配石英砂、特种聚合物改性剂为原料，采用薄贴工艺实现高效贴砖，提升施工效率，且具备优异耐磨性，可承受高人流量磨损... |
