Phospho-L-Tyrosine Disodium Salt in pharmaceutical and biotechnology development,
In pharmaceutical and biotechnology development, Phospho-L-Tyrosine Disodium Salt functions as a structural template for designing tyrosine kinase inhibitors (TKIs) and phosphatase modulators, which are key therapeutic agents for cancer, autoimmune diseases, and metabolic disorders. Its phosphate ester moiety mimics the phosphorylated state of kinase substrates, aiding in the development of competitive inhibitors. As a cell culture supplement, it is added to specialized media to regulate cell signaling and function—for example, promoting stem cell differentiation (neural or osteoblastic) by activating phosphorylation-dependent pathways or modulating immune cell (T lymphocyte, macrophage) activation in immunotherapy research. It is also used as an immunogen: conjugated to carrier proteins (e.g., BSA, KLH), it immunizes animals to generate phospho-specific antibodies against tyrosine-phosphorylated epitopes, which are essential tools for studying disease-related phosphorylation abnormalities.
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