N-terminal Pro B Type Natriuretic Peptide (NT-proBNP)
NT-proBNP is a product released under the pressure load of the heart, and its level can reflect the myocardial function and damage degree, which is related to the severity of heart failure. It is one of the most clinically used heart failure biomarkers.
N terminal probnp has essential value in the clinical diagnosis, risk stratification, prognosis evaluation, and curative effect monitoring of patients with acute heart failure (AHF) and chronic heart failure (CHF).
This precursor molecule is cleaved to form the active BNP and the inactive probnp n terminal-BNP (NT-proBNP) fragment. Myocardial cells secreted NT-proBNP in response to increase volume and pressure. Comparisons of BNP and NT-proBNP have shown that both eight molecules effectively diagnose left ventricular dysfunction in the acute care/emergency setting.
NT-proBNP Intro
Serum marker detection is an important means for the early diagnosis and prognosis of heart failure in clinical practice. The heart failure guidelines recommend the preferred serum markers for heart failure. Among them, n terminal pro b type natriuretic peptide (a neuroendocrine system activation marker), including brain natriuretic peptide (BNP) and amino-terminal brain natriuretic peptide (NT-proBNP), are the most popular at home and abroad (ECS/ACC/AHA/HFSA/CSC). It is recommended to use natriuretic peptides to identify high-risk heart failure groups and comprehensively manage and prevent them.
Compared with BNP, NT-proBNP has a longer half-life and better stability, so NT-proBNP has higher sensitivity for detecting early or mild heart failure, and it takes more time for blood samples to be sent to the laboratory making it possible more suitable for clinical applications.
NT-proBNP Test
Because NT-proBNP has a long half-life and is relatively more stable, the specimens can be stored and detected either in the central laboratory or at the bedside, while BNP has a short half-life and poor stability and can only be detected immediately at the bedside. NT-proBNP is slowly cleared in the blood and can accumulate at a higher concentration, reflecting the state and changes of cardiac function more sensitively to a certain extent, especially in the early diagnosis of heart failure. In addition, NT-proBNP has no physiological activity and is not affected by recombinant human brain natriuretic peptides (such as neoactivin). For patients treated with recombinant human brain natriuretic peptides, it is recommended to prefer NT-proBNP to evaluate the changes in cardiac function. BNP is cleared by binding to BNP clearance receptors neutral endonucleases, and a small part of it is emptied by renal metabolism. NT-proBNP is mainly removed by renal metabolism, so its concentration is more significantly affected by renal function than BNP.
As a professional tumor marker factory, SEKBIO has high-quality inflammatory marker for sale. Welcome to contact us if needed.
Other supplier products
|
|
Thyroid Stimulating Hormone Receptor (TSHR) |
The TSH receptor is a member of the G protein-coupled receptor superfamily of integral membrane proteins.
The thyrotropin receptor (or TSH recep... |
|
|
Cardiac Troponin I (cTnI) |
Cardiac troponin I, often denoted as cTnI, is presented in cardiac muscle tissue by a single isoform with a molecular weight of 23.9 kDa. Cardiac t... |
|
|
25-OH Vitamin D |
Vitamin D is converted to 25-hydroxyvitamin D (25-OH-VD) by hydroxylation in the liver and the active 1, 25-dihydroxy vitamin D in the kidneys.
... |
|
|
Thyroid Function |
Thyroid Function
The thyroid gland is a 2-inches long, butterfly-shaped endocrine gland generally located in the lower front of the neck. The ... |
|
|
N-terminal Pro B Type Natriuretic Peptide (NT-proBNP) |
NT-proBNP is a product released under the pressure load of the heart, and its level can reflect the myocardial function and damage degree, which is... |
All supplier products
Same products
|
|
Recombinant COVID-19 Spike 1 His Full Length Protein |
Seller: Shenzhen SEKBIO Co., Ltd |
Catalog #: HP811-16
Description: Recombinant Protein, research use only
Molecular weight: 29KD,... |
|
|
Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA II Tumor Marker) |
Seller: Shenzhen SEKBIO Co., Ltd |
In the absence of vitamin K, liver cells cannot depend on vitamin K in the synthesis of standard ... |
|
|
Prostate-Specific Antigen (PSA Tumor Marker) |
Seller: Shenzhen SEKBIO Co., Ltd |
Prostate-specific antigen （PSA specific antigen）, also known as gamma-selenoprotein or kallikrein... |
|
|
N-terminal Pro B Type Natriuretic Peptide (NT-proBNP) |
Seller: Shenzhen SEKBIO Co., Ltd |
NT-proBNP is a product released under the pressure load of the heart, and its level can reflect t... |
|
|
Mouse Myo mAb |
Seller: Shenzhen SEKBIO Co., Ltd |
Myo antibody Name: Myo mAbMouse mAb Catalog No. GSA501 Description: Epitope Mouse SEKBIO IVD Raw... |
