Metabolic Characteristics of Nisin

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Nisin is classified as a GRAS (Generally Recognized as Safe) substance by the FDA and FAO/WHO, with a long history of safe application in food production. Its safety is supported by toxicological data, metabolic characteristics, and regulatory standards.
Metabolic Characteristics of Nisin
Nisin is not accumulated in the human body. After oral ingestion, it is completely degraded into amino acids (alanine, serine, etc.) in the stomach and intestines within 2–4 hours, which are then absorbed and utilized for protein synthesis or energy metabolism. Unlike chemical preservatives (e.g., sodium benzoate), it does not undergo liver metabolism or produce toxic metabolites, making it safe for special populations such as infants, pregnant women, and individuals with liver/kidney disorders (within recommended doses).

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