Eptifibatide
|
Product Name |
Eptifibatide; |
|
Sequence |
Mpr-Har-Gly-Asp-Trp-Pro-Cys-NH2 |
|
Cas No. |
|
|
Molecular Formula |
C35H49N11O9S2 |
|
Molecular Weight |
832.4 |
|
Appearance |
White slightly yellwish powder |
|
Specific Rotation[20/D] |
-75.0～-95.0°（C=1，1%HAc） |
|
Amino Acids composition |
± 10% |
|
Peptide Purity (By HPLC) |
≥98% by area integration |
|
Related Substance (By HPLC) |
Total Impurities (%)≤2.0% Largest Single Impurity (%)≤ 1.0% |
|
Water Content (Karl Fischer) |
≤8.0% |
|
Peptide Content(N determination) |
≥80% |
|
Acetate Content |
≤15% |
|
IR spectrum |
in accordance |
Brief introduction:
Eptifibatide (Integrilin, Millennium Pharmaceuticals, also co-promoted by Schering-Plough/Essex), is an antiplatelet drug of the glycoprotein IIb/IIIa inhibitor class.[1] Eptifibatide is a cyclic heptapeptide derived from a protein found in the venom of the southeastern pygmy rattlesnake (Sistrurus miliarius barbouri).
It belongs to the class of the so-called arginin-glycin-aspartat-mimetics and reversibly binds to platelets. Eptifibatide has a short half-life. The drug is the third inhibitor of GPIIb/IIIa that has found broad acceptance after the specific antibody abciximab and the non-peptide tirofiban entered the global market.
Indications
Eptifibatide is used to reduce the risk of acute cardiac ischemic events (death and/or myocardial infarction) in patients with unstable angina or non-ST-segment-elevation (e.g., non-Q-wave) myocardial infarction (i.e., non-ST-segment elevation acute coronary syndromes) both in patients who are to receive non surgery (conservative) medical treatment and those undergoing percutaneous coronary intervention (PCI).
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