Apigenin

Apigenin CAS No. 520-36-5

Product name	Apigenin
CAS NO	520 36 5
Apigenin Chemical Formula	C15H10O5
Apigenin Molecular Weight
Specifications	95%, 98%
Test Method	HPLC
Appearance	Yellow needle crystal
Apigenin Solubility in Water	Almost insoluble in water, partially soluble in hot alcohol, soluble in dilute KOH solution.

Apigenin, or called apigenin extract, is a kind of natural flavonoid compounds, which exists as the yellow plant pigment in many plants. Apigenin mainly comes from the apium grhinensis and partly from the chamomile, bee balm, basil, verbena, and yarrow.

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Apigenin Health Benefits

There are many benefits of Apigenin, as following:

Benefits of Apigenin for Hair

Apigenin is a bioflavonoid compound found in plants and has powerful antioxidant properties. Researchers also believe that Apigenin, which is used for hair loss, may also inhibit a harmful androgen-inducing protein called TGF-B1. This compound of apigenin helps regulate the course of the hair follicle life cycle. Apigenin used in hair follicles may inhibit a compound called TGF-B1. Chamomile tea is a rich source of apigenin. However, drinking tea alone does not cure hair loss.

Apigenin and Cancer

Apigenin is a very potent anticancer compound. Highly selective for cancer cells and can selectively induce apoptosis of cancer cells without damaging normal cells, apigenin also has a very high safety threshold and an active (anti-cancer) dose which can be obtained by eating vegetables and fruits. Apigenin beneficially affects most types of cancer.

Benefits of Apigenin for Sleep

Apigenin is a very potent anticancer compound. It is highly selective for cancer cells and can selectively induce apoptosis of cancer cells without damaging normal cells. Apigenin also has a very high safety threshold and an active (anti-cancer) dose can be obtained by eating vegetables and fruits. Apigenin beneficially affects most types of cancer.

What is Apigenin Used for?

Apigenin is one type of citrus aurantium fructus extracts and has health benefits, so apigenin is also made into health products, medicines, and so on. Apigenin is a flavonoid that has the activity of inhibiting carcinogenic substances. Apigenin can be used as antivirals to treat HIV and other viral infections and as an inhibitor of MAP kinase. Like other bioflavonoids, apigenin reduces oxidative stress, induces cell cycle inhibition, increases the efficacy of liver detoxifying enzymes, and acts to some extent as an anti-inflammatory.

What is Apigenin Mechanism of Action?

Inhibition of NO production: NO is believed to have good effects, such as preventing thrombosis and inflammatory reaction, but it also has certain toxic effects. NO can react with superoxide anion (0-2) to form peroxynitrite (ONOOH). Apigenin is the strongest inhibitor of PGE and nitrite production, significantly superior to other flavonoids. It was found that apigenin plays its role by inhibiting the expression of COX-2 and iNOS at the cellular transcriptional level.

Is Apigenin Safe?

The radiation resistance of Apigenin is particularly strong. Apigenin can prevent a variety of radioactive substances harmful to the human body. Those who often contact the source of radiation can add some apigenin, reducing the radiation damage to a minimum. Apigenin also has a very positive effect on the human liver. Apigenin can improve the ability of the liver to detoxify and prevent damage caused by drugs to the liver. In addition, apigenin can prevent the occurrence of liver fibrosis.

What's Apigenin Supplement Side Effects?

Apigenin is a natural substance that can prevent and combat cancer. However, there are different studies on the effect of apigenin on chemotherapy agents. While the compound kills cancer cells, some cells become resistant to apigenin. In a study of leukaemia cells, the flavonoid was found to reduce the toxicity of the chemotherapy agent adriamycin. This means apigenin could increase the severity of the use of this agent in the treatment of leukemia.

What Foods Are High in Apigenin？

Apigenin is widely distributed in vegetables and fruits in warm tropics, such as celery, garlic, apples, oranges, etc., especially in celery. In addition, apigenin also exists in many Chinese herbal medicines, like ground money, Tibetan snow lotus, plantain, stone rattan, and so on. Apigenin is also found in plant-based beverages such as tea, wine, and some condiments. It is also found in other plants like chamomile, honeybee, Perilla, verbena, and yarrow. Apigenin can be mixed with vitamin B1, vitamin B6, vitamin B12, vitamin C, etc. And can also be mixed with plant essential oils like chamomile oil, calendula oil, almond oil, etc.

Technical Data Sheet (TDS) of Apigenin Extract Powder

Assay Item	Standard	Test Result
Assay( on dry Product)	≥95.0% ≥98.0%	≥95.0%（HPLC） ≥98.0%（HPLC）
Appearance	Pale yellow powder	Conforms
Identify	Positive	Positive
Heavy metals	≤10ppm	＜10ppm
As	≤1ppm	＜1ppm
Cd	≤1ppm	＜1ppm
Pb	≤1ppm	＜1ppm
Hg	≤0.1ppm	＜0.1ppm
Water	≤5.0%	＜0.1ppm
Sulphated ashes	≤2.0%	Conforms
Solvent residue	≤5000ppm	Conforms
Particle size	95% through 80 mesh	Conforms
Bacteria	≤1000cfu/g	Conforms
Mould and Yeast	≤100cfu/g	Conforms
Salmonella	Negative	Conforms
Escherichia coli	Negative	Negative
Staphylococcus aureus	Negative	Negative

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