Buffer Dilution/ Conditioning System

Bio-Con® auto dilution systemis to mix various concentrated buffer solutions, including acid, alkali, salt, etc., with injection water online to prepare the required buffer solution. Different concentrations can be accurately prepared according to specific usage situations. The online dilution and preparation system can quickly achieve stable control parameters. It can also be integrated with the Bio-Pro® pilot & process chromatography system or Bio-TFF tangential flow filtration system as a whole, continuously completing the process of "preparation + chromatography or preparation + tangential flow filtration", overall control and data recording. The overall system is based on DCS+BATCH system control, which can achieve centralized management, centralized control, batch processing, and batch control of the system, with a higher degree of automation.

The Difference Between Dilution And In-Line Dilution

The Inline Dilution System is similar to the two-pump gradient mode and allows for buffer dilution within a certain range. However, given the solubility of the mother liquor, pH shift after dilution and other phenomena, the robustness of buffer formulation is limited in large-scale applications.

The in-line conditioning system uses a single component mother liquor of acid system, base system, salt system, water and additive system to perform buffer formulation, simulating the traditional laboratory formulation mode, with corresponding pH and conductivity feedback adjustment added during the formulation process for improving buffer preparation stability.

The in-line buffer configuration is a single-component buffer concentrate with high solubility and can therefore be diluted up to a hundred times, which allows the volume of the buffer tank to be reduced a hundred times and can really solve the efficiency of room utilisation in the dispensing room or between uses.

It is possible to obtain an in-line buffer configuration system that has obvious advantages over in-line dilution systems in terms of scalability and adaptability, and at the same time provides a better solution for modern buffer preparation.

The Need For In-Line Automatic Buffer Conditioning Systems

Buffer preparation for chromatography and filtration steps in bioprocessing is a challenge in terms of providing timely buffer delivery, reproducibility, and good process economics.

Traditionally, buffer preparation relies mostly on manual work, which is labour-intensive and makes it difficult to avoid human errors, such as inaccurate weighing or deviations in the dosing of injection water for dilution. In addition, the target buffer must pass various quality control tests before it can be used in production, resulting in long dispensing cycles. The tanks must also be thoroughly cleaned and validated if they are used for other liquids. Another issue that should not be overlooked is that these large dispensing and storage tanks take up a lot of money and plant space.

We provide dilution system cleaning, dilution equipment, automated dilution machine, dilution control, dilution dispenser, etc. For more information about preparation of pharmaceutical buffer solution, please feel free to contact us!

Other supplier products

	Chromatographic Column	Hanbon medium and high pressure pilot scale chromatography columninclude DAC（dynamic axial compression）columns and laboratory columns. In 2005, Han...
	Membrane Cassette Holders	Membrane filter holderare package holders for deep filtration, ultrafiltration, and nanofiltration that range in size from 0.1 m² to 20 m²...
	Preparative HPLC	Hanbon offers Hanbon preparative HPLCand MPLC from laboratory to industrial level, which are essential tools for the isolation and purification of ...
	Chromatography System	Hanbon advanced chromatography systemshas reliable performance and flexible configuration, and can provide Bio-Lab® laboratory chromatography s...
	Biopharm Purification Equipment	Biopharm purification equipment independently developed by Hanbon includes Chromatography columns, Chromatography system, In-line buffer dilution s...

供应产品

Same products

	便携式木枕木 钻孔机	卖方: 武汉联科瑞际轨道设备有限公司
	ABS 塑料坐浴盆，带木制双喷嘴附件	卖方: 厦门特派智能科技有限公司	介绍我们的一键式快速释放坐浴盆，其特点是非电动木制双喷嘴附件，与大多数马桶盖板兼容。其凹形喷嘴顶部确保最佳功能，提供清爽卫生的清洁体验。使用这种方便高效的坐浴盆解决方案升级您的浴室。 ...
	Установки нанесения двухкомпанентного клея Установка для нанесения клея	卖方: 824681	Большой ЖК-экран CAD-файл может быть импортирован и превращен в шаблоны выдачи, а также загружен...
	Inconel alloy Superalloy CNC Machining Services	卖方: 新航金属制品有限公司	英科乃尔合金高温合金 CNC 加工服务简介 英科乃尔合金是一类高性能镍基高温合金，以其出色的强度、抗氧化性和耐高温环境能力而闻名。这些材料广泛应用于航空航天、发电和化学加工行业，这些行业的部件必...
	Titanium Alloy 3D Printing Prototyping Service	卖方: 新航金属制品有限公司	钛合金 3D 打印原型服务简介 钛合金因其出色的强度重量比、出色的耐腐蚀性和在高温环境下的出色性能而受到广泛认可。这些特性使其成为航空航天、医疗、汽车和船舶行业中性能和耐用性至关重要的关键应用的...