Paracetamol Tablets
Generic name: acetaminophen tablets
English name: paracetamol Tablets
The main component of this product is acetaminophen.
【Properties】
This product is a white piece.
Chemical name: N-(4 - hydroxyphenyl) acetamide. Molecular formula: C8H9NO2 MW: 151.16
Pharmacology and toxicology
This product is acetanilide class of antipyretic analgesics. Reach the antipyretic effect by inhibition of cyclooxygenase, selective inhibition of the hypothalamic thermoregulatory center of prostaglandin synthesis, resulting in peripheral vasodilatation, sweating, the strength of its antipyretic effects similar to aspirin; by inhibiting prostaglandin the synthesis and release play a role in analgesia improve pain threshold, belonging to the peripheral analgesic more effective than aspirin is weak, only mild to moderate pain effectively. This product has no anti-inflammatory effects.
Pharmacokinetics]
This product is rapidly absorbed after oral administration and completely absorbed in the body evenly distributed. 0.5 to 2 hours after oral administration, peak plasma concentration. Plasma protein binding rate is about 25% to 50%. This product is 90% to 95% metabolized in the liver, the major metabolite of glucuronic acid and sulfuric acid conjugates. Mainly in the form of glucuronidation, excretion from the kidneys within 24 hours, about 3% unchanged in the urine. The plasma half-life of l ~ 3 hours, renal insufficiency, the half-life is not affected, but patients with liver dysfunction and newborns, the elderly half-life is prolonged, and children has been shortened. Through the milk secretion.
Indications
Antipyretic and analgesic drugs for fever, headache, joint pain.
Dosage
Oral time 0.3 ~ 0.6g (l The first ~ 2 tablets), according to need day 3 to 4 times a day dosage should not exceed 2g (7 tablets). Antipyretic treatment is generally not more than three days, analgesic administration over 10 days straight. Children according to the weight of a 10 to 15mg/kg, every 4 to 6 hours; 12 children under the age of not more than five times every 24 hours dose regimen is not more than five days. This product is not long-term use.
Adverse reactions
Conventional doses, adverse reactions to acetaminophen rarely, occasionally can cause nausea, vomiting, sweating, abdominal pain, pale skin, and so on, a small number of cases can occur in atopic dermatitis (rash, pruritus, etc.), agranulocytosis, thrombocytopenia reduction in methemoglobinemia, anemia, liver and kidney dysfunction, and rarely cause gastrointestinal bleeding.
Of taboos
Patients with severe liver and kidney dysfunction, and those who are allergic to the chemicals disabled.
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