H3K36me3

As one of the professional custom peptide synthesis companiesin China, KS-V Peptide has been specialized in providing customized peptides synthesisservices(including Toxins and Analogues, Ubiquitins and Ubiquitin Probes, Post-translational Histones and other peptide manufacturing, APIs and process optimization of the pharmaceutical peptide.

SPECIFICATION OF H3K36ME3

CAT	H3112
Product Name	Histone H3-K36me3
Purity	≥95% by HPLC analysis
Appearance	White powder
Usage	Research use only
Storage	Shipping at room temperature. Upon delivery aliquot. Stored at -20°C or -80°C. Avoid freeze/thaw cycle.
Sequence	ARTKQTARKS TGGKAPRKQL ATKAARKSAP ATGGVK(me3)KPHR YRPGTVALRE IRRYQKSTEL LIRKLPFQRL VREIAQDFKT DLRFQSSAVM ALQEACEAYL VGLFEDTNLC AIHAKRVTIM PKDIQLARRI RGERA

APPLICATION OF H3K36ME3

H3K36me3 can bind chromodomain proteins such as MSL3 hMRG15 and scEaf3. It can bind PWWP proteins such as BRPF1 DNMT3A, HDGF2 and Tudor domains such as PHF19 and PHF1. H3K36me3 is required for homologous recombinational repair of DNA damage such as double-strand breaks. The trimethylation is catalyzed by SETD2 methyltransferase. H3K36me3 acts as a mark for HDACs to bind and deacetylate the histone which would prevent run-away transcription. It is associated with both facultative and constitutive heterochromatin.

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