HPMC E15
KimaCell®HPMC E15 Hydroxypropylmethylcellulose is a water-soluble cellulose polymer that helps optimize the solubility enhancement of poorly soluble drugs by maintaining a stable solid dispersion and inhibiting API crystallization.
More sophisticated drug discovery techniques have resulted in pipeline compounds requiring enhanced solubility to achieve therapeutic efficacy. Solid dispersion is one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. HPMC E15is specifically designed for the production of solid dispersions in the pharmaceutical industry by spray drying or hot melt extrusion.
HPMC E15 Properties
HPMC E15 |
|
Hydroxypropyl Methyl Cellulose (HPMC) |
|
Physical Analysis |
|
Appearance |
White to slightly off-white fibrous or granular powder. |
Identification A to E |
Conform |
Solution appearance |
Conform |
Methoxy |
|
Hydroxypropoxy |
|
Loss on drying |
|
Residue on ignition |
|
pH |
|
Apparent viscosity |
12-18cps |
Particle size |
|
Heavy Metals |
|
Heavy Metal |
≤10ppm |
Arsenic |
≤3ppm |
Lead |
≤3ppm |
Mercury |
≤1ppm |
Cadmium |
≤1ppm |
Micro bacteria |
|
Total plate count |
≤1000cfu/g |
Yeast and Mould |
≤100cfu/g |
Coli form |
Absent/g |
Salmonella |
Absent/g |
HPMC E15 Viscosity
HPMC E15 refers to Hydroxypropyl Methyl Cellulose with a nominal viscosity of 12.0-18.0 centipoises (cPs). The viscosity of HPMC E15 can vary slightly depending on the concentration and temperature of the solution it is dissolved in. However, the nominal viscosity value of 12-18 mPa.s provides a general indication of its viscosity range.
Viscosity is a measure of a fluid's resistance to flow. In the case of HPMC E15, the higher viscosity indicates that it forms a more viscous solution compared to lower viscosity grades of HPMC. This property makes it suitable for applications that require thicker and more stable formulations.
It's important to note that the viscosity of HPMC E15 can be further adjusted by varying the concentration of the HPMC powder in the solution. Higher concentrations of HPMC will generally result in higher viscosity solutions.
When using HPMC E15 in formulations, it is advisable to consult the manufacturer's technical data sheet or product specifications for precise information on viscosity and recommended usage levels. The technical data provided by the manufacturer will offer detailed information on the viscosity range, methods of measurement, and guidelines for formulating with HPMC E15.
HPMC E15 Uses
KimaCell® HPMC E15 is widely used in pharmaceutical excipients.
Tablet adhesive
HPMC E15 can be used as a binder for wet granulation of tablets at 3-5% of the finished tablet weight. HPMC E15 produces stronger granules compared to granules made with HPMC E15, which means that disintegration and dissolution times may be affected as harder tablets are produced.
Thickener and suspending agent
HPMC E15 can be used as a viscosity modifier in many cream, ointment, suspension formulations, including ophthalmic formulations.
KimaCell E15 grade is used in systems where high transparency is required and ease of filtration is an important parameter.
As one of cellulose ether suppliers, we will do our best to meet all the needs of customers.
在线联系供应商
Other supplier products
CMC HV | KimaCell® CMC HVsodium carboxymethyl cellulose is generally believed that when the degree of substitution is around 0.6-0.7, the emulsifying pe... | |
HPMC F4M | KimaCell®HPMC F4M Hydroxypropyl methylcellulose is used as a binder and disintegrant. Low-viscosity HPMC dissolves in water to form a clear to ... | |
Hydroxypropyl Methylcellulose (HPMC) Wholesale | Mydroxypropyl Méthylcellulose(HPMC), also known as , is a non-ionic cellulose ether made from natural polymer such as refined cotton or wood... | |
HPMC K15 LV | KimaCell®HPMC K15LV Hydroxypropyl methyl cellulose, also known as cellulose hydroxypropyl methyl ether, is prepared from cellulose through ethe... | |
Hydroxyethylcellulose in Skin Care | Hydroxyethylcellulose in skin careis a cellulose thickener, emulsifier, and a stabilizer, which helps to create a consistent texture and improve th... |
Same products
LUBCON Thermoplex ALN 1001/00 50ml Oil Original New | 卖方: 广东聚广恒自动化设备有限公司 | Special properties. - High resistance towards oxidation and high temperatures. - High load carryi... | |
Kluberoil Lamora D 220 30ml Original Oil | 卖方: 广东聚广恒自动化设备有限公司 | Good demulsifying behaviour towards water-miscible cooling lubricants · Optimised coeffici... | |
LUBE SH-ONE-4S 400G for Fanuc Machines | 卖方: 广东聚广恒自动化设备有限公司 | TheSH-ONEseries ofgreaseisoneof the latest released byLUBEand are used on a range of Fanuc machines | |
Mobil Grease 28 Synthetic Aviation Grease | 卖方: 广东聚广恒自动化设备有限公司 | Mobilgrease 28is the polyalphaolefin (PAO), clay-based multipurpose airframe and wheel bearing gr... | |
Kluber Isoflex Topas NCA 5051 50ml Original Lubricants | 卖方: 广东聚广恒自动化设备有限公司 | ISOFLEX TOPAS NCA 5051 is used in plain bearings in the automotive industry. ISOFLEX TOPAS NCA 50... |