Glycyl-glycyl-glycine
Toxicological safety evaluation of Glycyl-glycyl-glycine
Acute toxicity is extremely low: Animal experiments (such as oral ingestion in rats) have shown that the median lethal dose (LD₅₀) of triglycine is greater than 5g/kg body weight, which belongs to the "actually non-toxic" level (according to the FDA toxicity classification standard, LD₅₀>2g/kg is considered low-toxicity). This means that even short-term excessive intake is less likely to trigger acute poisoning reactions.
Chronic toxicity and accumulation: In the 90-day sub-chronic toxicity test, when rats were administered a daily dose of triglycine up to 1000mg/kg, no organic damage to organs such as the liver, kidneys, and blood system was observed, nor were there any signs of accumulation toxicity. Its metabolic product is glycine, which can be decomposed and utilized through normal amino acid metabolic pathways in the human body (such as participating in purine synthesis and glutathione generation), and will not accumulate in the body.
Genotoxicity and teratogenicity: Multiple genotoxicity tests such as the Ames test (bacterial mutation test) and chromosomal aberration test have shown that triglycine has no mutagenic effect. In the teratogenicity test, when pregnant rats were administered a dose as high as 2000mg/kg, there were no significant differences in the developmental indicators (such as body weight and organ morphology) of the fetal rats compared with the control group, proving that there was no teratogenicity risk.
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