Thyroid Stimulating Hormone Receptor (TSHR)
The TSH receptor is a member of the G protein-coupled receptor superfamily of integral membrane proteins.
The thyrotropin receptor (or TSH receptor) locates primarily in the body of the thyroid gland. It recognizes and binds to stimulating thyroid hormone (also known as "thyrotropin") secreted from the pituitary gland.
TSH stimulates the production of thyroxine (T4) and triiodothyronine (T3).
TSHR is closely related to the pathogenesis of various autoimmune thyroid diseases and is an essential indicator for the clinical diagnosis of these diseases.
SEKBIO is now offering Mouse anti-human TSHR mAb, Humanized anti-human TSHR mAb, Recombinant human sTSHR (Soluble), and human TSHR extractive of cell membranes (Full length) for diagnosis usage.
Types Of Thyroid Stimulating Hormone Receptor (TSHR)
|
Name |
|
Mouse Anti-human TSHR mAb |
|
Humanized Anti-human TSHR mAb |
|
Recombinant Human sTSHR (Soluble) |
|
Human TSHR Extractive of Cell Membrance (Full Length) |
TSHR
Thyroid-stimulating hormone receptor (TSHR) and its homologous luteinizing hormone/chorionic gonadotropin receptor and follicle-stimulating hormone receptor belong to a class of glycoprotein receptors. They are also visual A member of the large family of G protein-coupled receptors (GPcRs) of rhodopsin (approximately 45% identity at the amino acid level). TSHR is mainly expressed in thyroid follicular cells and activates the protein kinase A (PKA) and phospholipase C (Phospholipases C, PLc) signal transduction systems after combining with thyroid-stimulating hormone (TSH) under physiological conditions. , regulate the growth and differentiation of the thyroid, and promote the synthesis and release of thyroid hormones.
Anti TSH Antibody
The expression of TSHR can also be found in other cells or tissues, including adipocytes, fibroblasts, osteoblasts and osteoclasts, bone marrow cells and cardiomyocytes, etc., and is expressed in embryonic stem cells at an early stage. In autoimmune thyroid diseases, especially toxic diffuse goiter (Graves' disease, GD), TSHR can act as an autoantigen and bind to thyroid-stimulating antibody (TSAb) to produce TSH-like stimulation. The reaction will eventually lead to the loss of thyroid autoimmune tolerance, production and release of excessive thyroid hormones, and clinical manifestations of hyperthyroidism such as palpitations, sweating, and hyperthyroidism. Therefore, studying the structure of thyroid-stimulating hormone receptors and elucidating the interaction between autoantibodies and thyroid-stimulating hormone receptor (TSHR) molecules is vital for understanding Graves disease's pathogenesis, a common organ-specific autoimmune disease, and guiding clinical practice. Diagnosis and treatment have far-reaching significance.
Sekbioprovide tshr thyroid, tsh receptor test, tsh blocking antibodies, tsh stimulating antibodies, tsh stimulating immunoglobulin, thyroid stimulating immunoglobulin and tsh receptor antibodies, tshr test, ivd antigenand etc. want to know tshr normal rangeor more, contact us.
在线联系供应商
Other supplier products
 |
Thyroid Peroxidase (TPO) | Thyroid peroxidase igg(TPO), also called thyroperoxidase or iodide peroxidase tpo, catalyzes the iodization of thyroglobulin tyrosine during the bi... |
 |
Thyroid Peroxidase (TPO) | Thy peroxidase(TPO), also called thyroperoxidase or thyroid peroxidase igg, catalyzes the iodization of thyroglobulin tyrosine during the biosynthe... |
 |
CA19-9 | Cancer antigen 19-9 refers to a tumor marker associated with pancreatic, gallbladder, colon, and stomach cancers and is also known as an associated... |
 |
Triiodothyronine (T3) | Triiodothyronine, also known as T3, is a thyroid hormone. It affects almost every physiological process in the body, including growth and developme... |
 |
C-Peptide | The connecting peptide, or C-peptide, is a short 31-amino-acid polypeptide that connects insulin's A-chain to its B-chain in the proinsulin molecul... |
Same products
 |
RF4系列三目立体显微镜摇臂支架 | 卖方: 深圳维客修有限公司 | RF4 RF-FX23A RF-FX35A 7-50X连续变倍三目显微镜带折叠自由摆臂支架。RF4 RF-FX35A 7-50X三目立体显微镜带370mm摆动支架和RF-P016大硅胶焊盘，用于... |
 |
Medical Polyisoprene rubber pad for soft transfusion bag | 卖方: Taizhou KangLong Medical Treatment Technology Co., Ltd. | Medical Polyisoprene rubber pad for soft transfusion bag Stable production, Mature technology, Q... |
 |
The 51-piece Emergency Survival First Aid Bag | 卖方: Dongyang City Yonoel Outdoor Products Co., Ltd. | This Compact And Well-Organized First Aid Kit Is Designed To Provide A Wide Range Of Medical Supp... |
 |
RELIFE RL-M6T Pro B11 6.5X-65X Trinocular Stereo Microscope | 卖方: Phonefix | RELIFE RL-M6T Pro-B11 6.5X-65X Continuous Zoom Trinocular Stereo Microscope with B11 large area b... |
 |
Smoke Toxicity Tester | 卖方: 千实精密机电仪器检测设备有限公司 | TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi ... |
