Thyroid Stimulating Hormone Receptor (TSHR)
The TSH receptor is a member of the G protein-coupled receptor superfamily of integral membrane proteins.
The thyrotropin receptor (or TSH receptor) locates primarily in the body of the thyroid gland. It recognizes and binds to stimulating thyroid hormone (also known as "thyrotropin") secreted from the pituitary gland.
TSH stimulates the production of thyroxine (T4) and triiodothyronine (T3).
TSHR is closely related to the pathogenesis of various autoimmune thyroid diseases and is an essential indicator for the clinical diagnosis of these diseases.
SEKBIO is now offering Mouse anti-human TSHR mAb, Humanized anti-human TSHR mAb, Recombinant human sTSHR (Soluble), and human TSHR extractive of cell membranes (Full length) for diagnosis usage.
Types Of Thyroid Stimulating Hormone Receptor (TSHR)
|
Name |
|
Mouse Anti-human TSHR mAb |
|
Humanized Anti-human TSHR mAb |
|
Recombinant Human sTSHR (Soluble) |
|
Human TSHR Extractive of Cell Membrance (Full Length) |
TSHR
Thyroid-stimulating hormone receptor (TSHR) and its homologous luteinizing hormone/chorionic gonadotropin receptor and follicle-stimulating hormone receptor belong to a class of glycoprotein receptors. They are also visual A member of the large family of G protein-coupled receptors (GPcRs) of rhodopsin (approximately 45% identity at the amino acid level). TSHR is mainly expressed in thyroid follicular cells and activates the protein kinase A (PKA) and phospholipase C (Phospholipases C, PLc) signal transduction systems after combining with thyroid-stimulating hormone (TSH) under physiological conditions. , regulate the growth and differentiation of the thyroid, and promote the synthesis and release of thyroid hormones.
Anti TSH Antibody
The expression of TSHR can also be found in other cells or tissues, including adipocytes, fibroblasts, osteoblasts and osteoclasts, bone marrow cells and cardiomyocytes, etc., and is expressed in embryonic stem cells at an early stage. In autoimmune thyroid diseases, especially toxic diffuse goiter (Graves' disease, GD), TSHR can act as an autoantigen and bind to thyroid-stimulating antibody (TSAb) to produce TSH-like stimulation. The reaction will eventually lead to the loss of thyroid autoimmune tolerance, production and release of excessive thyroid hormones, and clinical manifestations of hyperthyroidism such as palpitations, sweating, and hyperthyroidism. Therefore, studying the structure of thyroid-stimulating hormone receptors and elucidating the interaction between autoantibodies and thyroid-stimulating hormone receptor (TSHR) molecules is vital for understanding Graves disease's pathogenesis, a common organ-specific autoimmune disease, and guiding clinical practice. Diagnosis and treatment have far-reaching significance.
Sekbioprovide tshr thyroid, tsh receptor test, tsh blocking antibodies, tsh stimulating antibodies, tsh stimulating immunoglobulin, thyroid stimulating immunoglobulin and tsh receptor antibodies, tshr test, ivd antigenand etc. want to know tshr normal rangeor more, contact us.
在线联系供应商
Other supplier products
 |
C-Peptide | The connecting peptide, or C-peptide, is a short 31-amino-acid polypeptide that connects insulin's A-chain to its B-chain in the proinsulin molecul... |
 |
Human Progastrin-releasing Peptide (ProGRP) | ProGRPtumormarkeris a recently identified biomarker of small cell lung cancer (SCLC). ProGRPtumor marker is a precursor of a neuropeptide hormone c... |
 |
Influenza (Flu) | Influenza virus is the representative species of the Orthomyxoviridae family. The typical clinical symptoms of these diseases are acute high fever,... |
 |
Testosterone (Testo) | Testosteroneis the primary male sex hormone and an anabolic steroid. In male humans, testosterone plays a vital role in developing male reproductiv... |
 |
Inflammatory Marker | Inflammatory cytokines refer to various cytokines involved in the inflammatory response. And the inflammatory markers can identify the severity and... |
Same products
 |
Maternity and baby products of Different Brands | 卖方: O&K GROUP LIMITED | Okwishing supplies all kinds of Maternity and baby products of Different Brands. Okwishing () is ... |
 |
Medical Equipment of Different Brands | 卖方: O&K GROUP LIMITED | Okwishing supplies all kinds of Medical Equipment of Different Brands. Okwishing() is a cross-b... |
 |
MECHANIC ROBOT 6560T-B11HD 三目立体显微镜 | 卖方: 深圳维客修科技有限公司 | 描述 机械师标准版6560T-B11三目立体显微镜，放大倍数6.5-60X，45度倾斜360度旋转观察头，带WF10X25可调目镜。非常适合维修手机、平板电脑、手表等电子产品，适用于电子电路板、... |
 |
Outdoor Sports First Aid Kit | 卖方: Dongyang City Yonoel Outdoor Products Co., Ltd. | Tactical First Aid Kit, Outdoor Sports First Aid Kit, Camping Survival Bag, Medical Supplies: Fir... |
 |
ZM-6552TH 0.65X - 5.2X 双目三目立体显微镜，适用于主板维修 | 卖方: 深圳维客修科技有限公司 | 描述 Greenough ZM-6552TH 0.65X-5.2X双目/三目立体变焦显微镜适用于手机主板/电子电路板CPU BGA焊接维修、珠宝鉴定修复、实验室观察、学术研究等。ZM-6552T... |
