CNV-seq Detection (Semiconductor Sequencing)

• 

CNV-seq Detection (Semiconductor Sequencing)

The detection kit, which is based on the BES 4000 platform, is used to perform low-depth whole-genome sequencing of DNA. The sequencing results are compared to the base sequence of the human reference genome, and CNVs in the tested samples are discovered using bioinformatics analysis. It is often used to find out why a woman keeps having miscarriages, find out what is wrong with an abnormal fetus, and help with a prenatal diagnosis.

What Are The Methods To Detect CNV?

There are four main methods for detecting CNVs using Next-Generation Sequencing (NGS) data: read-pair, split-read, read-depth, and assembly.

Read-Pair Method: This approach involves analyzing the distance between pairs of sequence reads. Deviations from the expected distance can indicate the presence of a CNV.

Split-Read Method: This method identifies CNVs by looking for reads that span a breakpoint. The portion of the read that aligns to the reference sequence can provide information about the CNV.

Read-Depth Method: This is the most commonly used method in NGS-based CNV detection. It works by comparing the depth of coverage in different regions of the genome. Regions with unusually high or low coverage can suggest a CNV.

Assembly Method: This approach involves assembling the reads into a new genome sequence and then comparing this sequence to the reference genome to identify CNVs.

Each of these methods has its strengths and limitations, and the choice of method often depends on the specific requirements of the study. CapitalBio Technology continues to innovate in this area, developing advanced tools and technologies to facilitate accurate and efficient CNV detection.

What Is The Principle Of CNV-Semiconductor Sequencing?

CapitalBioTechnology employs CNV-semiconductor sequencing, a specialized technique used to detect Copy Number Variations (CNVs) in the genome. CNVs are alterations of the DNA of a genome that results in the cell having an abnormal number of copies of one or more sections of the DNA.

The principle behind CNV-semiconductor sequencing involves the detection of these variations through the use of semiconductor technology. As the DNA is sequenced, the semiconductor chip detects the release of hydrogen ions, which corresponds to the incorporation of nucleotides into the DNA strand.

By comparing the sequencing data to a reference genome, CNV-semiconductor sequencing can identify regions where there are more or fewer copies of a particular DNA segment. This technique allows CapitalBio Technology to provide accurate and comprehensive genetic analysis, crucial for understanding genetic diseases and developing personalized treatments.

As one of sequencing companies, we will do our best to meet all the needs of customers.

Other supplier products

	Mycobacteria Species Identification	Identification of Mycobacterium NTM disease symptoms are strikingly similar to those of MTB disease symptoms, and NTM has an 83.7% insensitivity r...
	Individualized Medication Guidance for Gastrointestinal Cancer	This test detects 84 genes related to gastrointestinal cancer, provides information on targeted drug, chemotherapy, and hereditary risk assessment....
	Neuromuscular Disorders	Neuromuscular Disorders List Neuromuscular disorders include a wide-range of diseases affecting the peripheral nervous system, which consists of a...
	CapitalBio® Microarray Scanner LuxScan™10K	The CapitalBio LuxScan™ 10K dna microarray scanneris a compact high performance system for microarray imaging and the analysis of DNA, protei...
	Genetic Testing for BRCA1/2 Targeted-drug Guidance [ Germline + Somatic]	This germline testingdetects somatic and germline SNV, InDel and CNV mutations in the BRCA1 and BRCA2 genes, covering the entire coding region of t...

Same products

	Grey Rubber Stopper For Blood Collection Tube	Seller: Taizhou KangLong Medical Treatment Technology Co., Ltd.	Medical Grey Rubber Stopper For Blood Collection Tube Good formulation technology guarantees...
	Tactical First Aid Kit	Seller: Zhejiang Huaqi Information Technology Co., LTD	This first aid kit includes a comprehensive range of supplies, from bandages and gauze to tweezer...
	Camping Survival Bag	Seller: Zhejiang Huaqi Information Technology Co., LTD	The Tactical First Aid Kit Is An Essential Companion For Outdoor Sports Enthusiasts, Campers, And...
	ENHANCED VEGETAL VIGRA MALE SEX ENHANCEMENT CAPSULES	Seller: GLOBAL WEIGHT LOSS LTD	ENHANCED VEGETAL VIGRA ENHANCED VEGETAL VIGRA MALE SEX ENHANCEMENT CAPSULES ENHANCED VEGETAL VIGR...
	ORGANIC HONEY CANDY POWER	Seller: GLOBAL WEIGHT LOSS LTD	Organic Power Honey Candy for Men- Pack of 6 Candies ORGANIC POWER CANDY ORGANIC CANDY HONEY ORGA...