Nisin
Due to nisin's antibacterial activity against drug-resistant gram-positive bacteria (e.g., methicillin-resistant Staphylococcus aureus, MRSA), nisin is being researched for non-oral medical applications (it is broken down by gut enzymes, so oral use for systemic infections is limited):
Topical formulations: Developed into creams, ointments, or wound dressings to treat skin infections caused by gram-positive bacteria (e.g., MRSA-induced skin ulcers or burns). It is also tested in oral care products (e.g., mouthwashes, toothpaste) to inhibit Streptococcus mutans (the main bacterium causing tooth decay).
Medical device coatings: Coated on catheters, implants (e.g., orthopedic implants), or surgical instruments to prevent bacterial adhesion and biofilm formation (a major cause of hospital-acquired infections like catheter-related bloodstream infections).
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