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Thermal Stability
Heat Resistance in Acidic Media:
Retains activity after pasteurization (70–90°C) or even UHT processing (135–150°C) in acidic conditions (pH < 5).
For example, in acidic beverages, nisin can withstand high - temperature short - time (HTST) processing without significant loss of efficacy.
Reduced Stability in Neutral/Alkaline Media:
At neutral pH, heat stability decreases; prolonged exposure to temperatures above 100°C can degrade nisin, especially in alkaline conditions.
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Safety ·Non-toxic and Safe: Nisin is a safe, non-toxic, and highly effective natural preservative. Once ingested, it is easily broken down b... |
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Toxicological Safety of Nisin |
Acute and Chronic Toxicity: Acute toxicity studies show that Nisin has an LD₅₀ > 5000 mg/kg in rodents (oral administration), indicating extreme... |
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