Fumarate Vonoprazan, TAK-438
CAS No.1260141 27 2 Fumarate Vonoprazan
Vonoprazan fumarate fda approval (TAK-438), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan Fumarate inhibits H+, K+-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan Fumarate is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease.
Synonym
Vonaprazan; 5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine2-butenedioate(Vonoprazan); 1-[5-(2-fluorophenyl)-1-pyridin-3-Chemicalbookylsulfonylpyrrol-3-yl]-N-methylmethanamine; AK-438; Vonaprazan(TAK-438); vonoprazan(tak-438); Vonoprazanfumarate(TAK-438); vonoprazan(tak
CAS No.:
EC No.: 250-635-4
MF: C21H20FN3O6S
MW: 461.46
Parameters of Fumarate Vonoprazan, TAK-438
Item Specification Results
Appearance Off-white To White Crystalline Powder White Crystalline Powder
Solubility Soluble In Dmso, Slightly Soluble In Methanol, Water, Very Slightly Soluble In Alcohol. Complies
Identification 1HNMR Complies
Melting Point 196-201℃ 198-199℃
Residue On Ignition NMT0.2% 0.03%
Water NMT0.5% 0.12%
Single Impurity NMT0.1% 0.034%
Total Impurities NMT0.5% 0.121%
Heavy Metals NMT20PPM Complies
Assay 99.0-101.0% 99.69%
Packing:
100g/bag; 500g/bag; 1kg/bag; 25kg/drum
Recommended storage method:
Store in a cool, dry and ventilated place.
Recommended storage temperature:
2 - 8 °C
Product usage:
Antigastric drugs
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