Crospovidone, PVPP
Crospovidone, PVPP
Pharmaceutical-grade Crospovidone (PVPP), a highly crosslinked and water-insoluble PVP polymer for rapid tablet disintegration. It absorbs water and swells without forming a high-viscosity gel, making it suitable for direct-compression and wet-granulation tablet formulations.
Yuking Crospovidone XL/XL-10 is a crosslinked polyvinylpyrrolidone, also known as Crospovidone or PVPP, for pharmaceutical tablet and granule formulations.
Crospovidone is a water-insoluble polymer with a highly crosslinked network structure. When it comes into contact with water, it absorbs liquid and swells rapidly, helping the tablet matrix break apart without forming a high-viscosity gel.
This makes Crospovidone XL/XL-10 suitable for formulations where rapid tablet disintegration, efficient liquid penetration and reliable solid-dose performance are required.
Product Name: Crospovidone XL/XL-10
Pharmacopoeial Name: Crospovidone
Common Name: Crosslinked PVP / PVPP
Main Function: Tablet disintegrant, adsorbent and complexing support material
Standard Packaging: 25 kg cardboard drum
Key Product Characteristics
|
Property |
Description |
|
Polymer Type |
Highly crosslinked polyvinylpyrrolidone |
|
Solubility |
Insoluble in water, ethanol and chloroform |
|
Water Interaction |
Rapid water absorption and swelling |
|
Gel Formation |
Does not form a high-viscosity gel |
|
Primary Role |
Tablet disintegration support |
|
Process Compatibility |
Can be evaluated for direct compression and wet granulation |
|
Appearance |
White or off-white powder |
|
Odor |
Odorless or with a slight characteristic odor |
Quality Specifications
|
Test Item |
Specification |
|
pH, 1% Aqueous Suspension |
|
|
Water-Soluble Substances |
≤1.0% |
|
Residual N-Vinyl-2-Pyrrolidone |
≤10 ppm |
|
Peroxides, as H₂O₂ |
≤0.04% |
|
Moisture Content |
≤5.0% |
|
Residue on Ignition |
≤0.1% |
|
Heavy Metals |
≤10 ppm |
|
Arsenic |
≤2 ppm |
All values should be confirmed against the latest approved Technical Data Sheet and Certificate of Analysis before supplier qualification, registration or commercial production.
Why Choose Crospovidone XL/XL-10?
Crospovidone XL/XL-10 is designed for solid-dose formulations that need rapid water uptake and tablet break-up after administration.
Its crosslinked structure provides the following functional characteristics:
Strong water absorption and swelling capacity;
Does not form a high-viscosity gel after water uptake;
Supports rapid tablet disintegration;
Helps liquid penetrate the tablet matrix;
Suitable for direct-compression and wet-granulation formulation development;
Can be evaluated as an adsorbent or complexing material in selected pharmaceutical systems.
The final grade, particle-size profile, addition stage and use level should be determined through formulation trials and process validation.
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