BOC-L-GLU(ME)-OME
BOC-L-GLU(ME)-OME is one of the core starting materials for the synthesis of the oral anti-coronavirus drug parovetide (PF-07321332), which is used to construct the key chiral pyrrolidine ring structure in the drug molecule. Through steps such as condensation with bromoacetone, cyanide reduction, intramolecular amide hydrolysis cyclization, and deprotection to form salts, the key intermediate (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl] propionic acid methyl ester of parovetide can be efficiently prepared. The design of the chiral center and the protection group enables precise control of the stereospecificity of the cyclization reaction, ensuring the configuration purity of the drug molecule. This is an important foundation for achieving the large-scale synthesis of parovetide and reducing production costs.
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