H3K79ME2
Synthesized histone H3 peptide corresponding to residues within 1-135 of human histone H3 with dimethylation K79 modification.
SPECIFICATION OF H3K79ME2
CAT |
H3114 |
Product Name |
Histone H3-K79me2 |
Purity |
≥95% by HPLC analysis |
Appearance |
White powder |
Usage |
Research use only |
Storage |
Shipping at room temperature. Upon delivery aliquot. Stored at -20°C or -80°C. Avoid freeze/thaw cycle. |
Sequence |
ARTKQTARKS TGGKAPRKQL ATKAARKSAP ATGGVKKPHR YRPGTVALRE IRRYQKSTEL LIRKLPFQRL VREIAQDFK(me2)T DLRFQSSAVM ALQEACEAYL VGLFEDTNLC AIHAKRVTIM PKDIQLARRI RGERA |
APPLICATION OF H3K79ME2
Lysine 79 of histone H3 can be mono-, di- or trimethylated by Dot1 methylase; methylation at this residue acts as a marker of inactive chromatin regions that are critical for transcriptional silencing, and it is thought that silencing proteins such as Sir3 function by blocking Dot1 methylation. DOT1L-mediated H3K79me2 modification drives cardiomyogenesis through the definition of a specific transcriptional landscape.
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