.

PROTOXIN II

NaV channels and T-type Ca2+ channels, Protx-II inhibits NaV channels1. Protx-II could also modulate T-type Ca2+ channels at higher concentrations2.

SPECIFICATION OF PROTOXIN II

CAT

N1030-V

CAS NO.

Product Name

Protoxin II

Purity

> 98%

Form/State

Lyophilized powder

Solubility

Soluble in water

Molecular weight

Molecular formula

C169H274N54O48S7

Source

Synthetic peptide

Storage

Shipped at room temperature. The product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Storage of solutions

Up to two weeks at 4°C or three months at -20°C.

Sequence

RSCIDTIPKSRCTAFQCKHSMKYRLSFCRKTCGTC (Disulfide bonds: Cys3-Cys35, Cys12-Cys28 and Cys17-Cys32)

APPLICATION OF PROTOXIN II

Protoxin II, an inhibitory cystine knot toxin from the tarantula Thrixopelma pruriens, inhibits voltage-gated sodium channels.

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