PROTOXIN II

NaV channels and T-type Ca2+ channels, Protx-II inhibits NaV channels1. Protx-II could also modulate T-type Ca2+ channels at higher concentrations2.

SPECIFICATION OF PROTOXIN II

CAT	N1030-V
CAS NO.
Product Name	Protoxin II
Purity	> 98%
Form/State	Lyophilized powder
Solubility	Soluble in water
Molecular weight
Molecular formula	C169H274N54O48S7
Source	Synthetic peptide
Storage	Shipped at room temperature. The product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage of solutions	Up to two weeks at 4°C or three months at -20°C.
Sequence	RSCIDTIPKSRCTAFQCKHSMKYRLSFCRKTCGTC (Disulfide bonds: Cys3-Cys35, Cys12-Cys28 and Cys17-Cys32)

APPLICATION OF PROTOXIN II

Protoxin II, an inhibitory cystine knot toxin from the tarantula Thrixopelma pruriens, inhibits voltage-gated sodium channels.

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